Science Advances is the American Association for the Advancement of Science’s (AAAS) open access multidisciplinary journal, publishing impactful research papers and reviews in any area of science, in both disciplinary-specific and broad, interdisciplinary areas. The mission of Science Advances is to provide fair, fast, and expert peer review to authors and a vetted selection of research, freely available to readers. Led by a team of distinguished scientists and allowing flexible article formats, Science Advances supports the AAAS mission by extending the capacity of Science magazine to identify and promote significant advances in science and engineering across a wide range of areas. The journal’s use of evolving digital publishing technologies plays a critical role in building and sustaining AAAS’s mission as a global participant and advocate for the communication and use of science to benefit humankind.