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期刊名字 | JOURNAL OF MEDICINAL CHEMISTRY J. Med. Chem. （此期刊被最新的JCR期刊SCIE收录） LetPub评分 8.3
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声誉 8.9 影响力 7.7 速度 9.4 | |||||||||||||||||||||
| 期刊ISSN | 0022-2623 | 微信扫码收藏此期刊 | ||||||||||||||||||||
| E-ISSN | 1520-4804 | |||||||||||||||||||||
| 2022-2023最新影响因子 （数据来源于搜索引擎） | 7.3 点击查看影响因子趋势图 | |||||||||||||||||||||
| 实时影响因子 | 截止2023年9月27日：4.3 | |||||||||||||||||||||
| 2022-2023自引率 | 11.00%点击查看自引率趋势图 | |||||||||||||||||||||
| 五年影响因子 | 7.3 | |||||||||||||||||||||
| h-index | 240 | |||||||||||||||||||||
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| 期刊简介 | The Journal of Medicinal Chemistry发表分子结构与生物活性或作用模式之间关系的相关研究。 The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action. Some specific areas that are appropriate include the following: Design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools. Molecular modifications of reported series that lead to a significantly improved understanding of their structure-activity relationships (SAR). Routine extensions of existing series that do not utilize novel chemical or biological approaches or do not add significantly to a basic understanding of the SAR of the series will normally not be accepted for publication. Structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds. Molecular biological studies (e.g., site-directed mutagenesis) of macromolecular targets that lead to an improved understanding of molecular recognition. Computational studies that provide fresh insight into the SAR of compound series that are of current general interest or analysis of other available data that subsequently advance medicinal chemistry knowledge. Substantially novel computational chemistry methods with demonstrated value for the identification, optimization, or target interaction analysis of bioactive molecules. Effect of molecular structure on the distribution, pharmacokinetics, and metabolic transformation of biologically active compounds. This may include design, synthesis, and evaluation of novel types of prodrugs. Novel methodology with broad application to medicinal chemistry, but only if the methods have been tested on relevant molecules. | |||||||||||||||||||||
| 期刊官方网站 | https://pubs.acs.org/journal/jmcmar | |||||||||||||||||||||
| 期刊投稿网址 | https://acs.manuscriptcentral.com/acs | |||||||||||||||||||||
| 期刊语言要求 | 经LetPub语言功底雄厚的美籍native English speaker精心编辑的稿件，不仅能满足JOURNAL OF MEDICINAL CHEMISTRY的语言要求，还能让JOURNAL OF MEDICINAL CHEMISTRY编辑和审稿人得到更好的审稿体验，让稿件最大限度地被JOURNAL OF MEDICINAL CHEMISTRY编辑和审稿人充分理解和公正评估。LetPub的专业SCI论文编辑服务（包括SCI论文英语润色，同行资深专家修改润色，SCI论文专业翻译，SCI论文格式排版，专业学术制图等）帮助作者准备稿件，已助力全球15万+作者顺利发表论文。部分发表范例可查看：服务好评 论文致谢 。
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| 是否OA开放访问 | Transformative (TJ转换期刊是订阅式/混合期刊，但是正在积极转为完全开放获取期刊。查看ACS说明。) | |||||||||||||||||||||
| 通讯方式 | AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, USA, DC, 20036 | |||||||||||||||||||||
| 出版商 | American Chemical Society | |||||||||||||||||||||
| 涉及的研究方向 | 医学-医药化学 | |||||||||||||||||||||
| 出版国家或地区 | UNITED STATES | |||||||||||||||||||||
| 出版语言 | English | |||||||||||||||||||||
| 出版周期 | Biweekly | |||||||||||||||||||||
| 出版年份 | 1959 | |||||||||||||||||||||
| 年文章数 | 945点击查看年文章数趋势图 | |||||||||||||||||||||
| Gold OA文章占比 | 9.90% | |||||||||||||||||||||
| 研究类文章占比： 文章 ÷（文章 + 综述） | 99.89% | |||||||||||||||||||||
| WOS期刊SCI分区 （ 2022-2023年最新版） | WOS分区等级：1区
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| 中科院《国际期刊预警 名单（试行）》名单 | 2023年01月发布的2023版：不在预警名单中 2021年12月发布的2021版：不在预警名单中 2021年01月发布的2020版：不在预警名单中 | |||||||||||||||||||||
| 中科院SCI期刊分区 （ 2022年12月最新升级版） | 点击查看中科院SCI期刊分区趋势图
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| 中科院SCI期刊分区 （ 2021年12月基础版） |
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| 中科院SCI期刊分区 （ 2021年12月升级版） |
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| 中科院SCI期刊分区 （ 2020年12月旧的升级版） |
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| SCI期刊收录coverage | Science Citation Index Expanded (SCIE) (2020年1月，原SCI撤销合并入SCIE，统称SCIE) Scopus (CiteScore) | |||||||||||||||||||||
| PubMed Central (PMC)链接 | http://www.ncbi.nlm.nih.gov/nlmcatalog?term=0022-2623%5BISSN%5D | |||||||||||||||||||||
| 平均审稿速度 | 网友分享经验： 平均2.1个月 | |||||||||||||||||||||
| 平均录用比例 | 网友分享经验： 较难 | |||||||||||||||||||||
| LetPub助力发表 | 经LetPub编辑的稿件平均录用比例是未经润色的稿件的1.5倍，平均审稿时间缩短40%。众多作者在使用LetPub的专业SCI论文编辑服务（包括SCI论文英语润色，同行资深专家修改润色，SCI论文专业翻译，SCI论文格式排版，专业学术制图等）后论文在JOURNAL OF MEDICINAL CHEMISTRY顺利发表。
快看看作者怎么说吧：服务好评 论文致谢 | |||||||||||||||||||||
| 收稿范围 | 期刊官网数据： 期刊收录研究方向： 药理工具的新型生物活性化合物、诊断剂或标记配体的设计、合成和生物学评估 分子修饰以增进对构效关系（SAR）的认知。（没有创新性的化学或生物学方法或没有对SAR进行深入分析的常规工作通常将不予出版） 有关配体和靶标的结构生物学研究（X射线，NMR等），以探究生物活性化合物作用下的分子识别过程 大分子靶标的分子生物学研究（例如定点诱变）以增进对分子识别的理解 具有最新见解的化合物SAR计算研究，这些化合物当前具有普遍价值，或者可用于分析其他有用数据，从而进一步提高对药物化学的认知 新颖的计算化学方法，对于生物活性分子的鉴定、优化或标靶相互作用分析具有证明价值 分子结构对生物活性化合物的分布、药代动力学和代谢转化的影响。这可能包括新型药物前体的设计、合成和评估 可广泛应用于药物化学的新方法，且该方法已在相关分子上进行测试 | |||||||||||||||||||||
| 收录体裁 | 期刊官网数据： Articles Brief Articles Perspectives Drug Annotations Viewpoint Featured Articles | |||||||||||||||||||||
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| 中国学者近期发表的论文 | |
| 1. | Design, Synthesis, and Antitumor Activity of Potent and Selective EGFR L858R/T790M Inhibitors and Identification of a Combination Therapy to Overcome Acquired Resistance in Models of Non-small- cell Lung Cancer Author: Pei, Junping; Wang, Guan; Wang, Aoxue; Wu, Chengyong; Pan, Xiaoli; Shuai, Wen; Bu, Faqian; Zhu, Yumeng; Wang, Yuxi; Ouyang, Liang; Li, Weimin Journal: JOURNAL OF MEDICINAL CHEMISTRY. 2023; Vol. , Issue , pp. -. DOI: 10.1021/acs.jmedchem.3c00027 PubMed DOI |
| 2. | Discovery of Pyridinone Derivatives as Potent, Selective, and Orally Bioavailable Adenosine A2A Receptor Antagonists for Cancer Immunotherapy Author: Zhu, Chenyu; Ze, Shuyin; Zhou, Ronghui; Yang, Xinyu; Wang, Haojie; Chai, Xiaolei; Fang, Meimiao; Liu, Mingyao; Wang, Yonghui; Lu, Weiqiang; Xie, Qiong Journal: JOURNAL OF MEDICINAL CHEMISTRY. 2023; Vol. 66, Issue 7, pp. 4734-4754. DOI: 10.1021/acs.jmedchem.2c018604734J PubMed DOI |
| 3. | Targeting Receptor-Interacting Protein Kinase 1 by Novel Benzothiazole Derivatives: Treatment of Acute Lung Injury through the Necroptosis Pathway Author: Zhang, Xinqi; Han, Qianyu; Hou, Ruilin; Xu, Lijuan; Zhang, Wannian; Xing, Chengguo; Xue, Lei; Zhuang, Chunlin Journal: JOURNAL OF MEDICINAL CHEMISTRY. 2023; Vol. 66, Issue 7, pp. 5261-5278. DOI: 10.1021/acs.jmedchem.3c00197 PubMed DOI |
| 4. | Application and Study of ROCK Inhibitors in Pulmonary Fibrosis: Recent Developments and Future Perspectives Author: Xie, Yuting; Yue, Lin; Shi, Yaojie; Su, Xingping; Gan, Cailing; Liu, Hongyao; Xue, Taixiong; Ye, Tinghong Journal: JOURNAL OF MEDICINAL CHEMISTRY. 2023; Vol. 66, Issue 7, pp. 4342-4360. DOI: 10.1021/acs.jmedchem.2c01753 PubMed DOI |
| 5. | Development of Son of Sevenless Homologue 1 (SOS1) Modulators To Treat Cancers by Regulating RAS Signaling Author: Luo, Guangmei; Wang, Bingrui; Hou, Qiangqiang; Wu, Xiaoxing Journal: JOURNAL OF MEDICINAL CHEMISTRY. 2023; Vol. 66, Issue 7, pp. 4324-4341. DOI: 10.1021/acs.jmedchem.2c01729 PubMed DOI |
| 6. | Unsymmetrical Phosphodiesters as GPR84 Antagonists with High Blood Exposure for the Treatment of Lung Inflammation Author: Li, Shao-Xian; Wang, Si-Wei; Chen, Lin-Hai; Zhang, Qing; Lu, Dan; Chen, Jing; Fang, You-Chen; Gu, Min; Xie, Xin; Nan, Fa-Jun Journal: JOURNAL OF MEDICINAL CHEMISTRY. 2023; Vol. 66, Issue 8, pp. 5820-5838. DOI: 10.1021/acs.jmedchem.3c00053 PubMed DOI |
| 7. | Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1 Author: Gallego, Rebecca A.; Bernier, Louise; Chen, Hui; Cho-Schultz, Sujin; Chung, Loanne; Collins, Michael; Del Bel, Matthew; Elleraas, Jeff; Jones, Cinthia Costa; Cronin, Ciaran N.; Edwards, Martin; Fang, Xu; Fisher, Timothy; He, Mingying; Hoffman, Jacqui; Huo, Ruiduan; Jalaie, Mehran; Johnson, Eric; Johnson, Ted W.; Kania, Robert S.; Kraus, Manfred; Lafontaine, Jennifer; Le, Phuong; Liu, Tongnan; Maestre, Michael; Matthews, Jean; McTigue, Michele; Miller, Nichol; Mu, Qiming; Qin, Xulong; Ren, Shijian; Richardson, Paul; Rohner, Allison; Sach, Neal; Shao, Li; Smith, Graham; Su, Ruirui; Sun, Bin; Timofeevski, Sergei; Tran, Phuong; Wang, Shuiwang; Wang, Wei; Zhou, Ru; Zhu, Jinjiang; Nair, Sajiv K. Journal: JOURNAL OF MEDICINAL CHEMISTRY. 2023; Vol. 66, Issue 7, pp. 4888-4909. DOI: 10.1021/acs.jmedchem.2c02038 PubMed DOI |
| 8. | Exploration of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Bispecific Inhibitors Based on the Moiety of Fedratinib for Treatment of Both Hematologic Malignancies and Solid Cancers Author: Qiu, Qianqian; Chi, Fanglian; Zhou, Daoguang; Xie, Zhancheng; Liu, Yunxiao; Wu, Hanyu; Yin, Ziyu; Shi, Wei; Qian, Hai Journal: JOURNAL OF MEDICINAL CHEMISTRY. 2023; Vol. , Issue , pp. -. DOI: 10.1021/acs.jmedchem.3c00036 PubMed DOI |
| 9. | Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects Author: Peng, Xiaopeng; Ren, Yichang; Pan, Wanyi; Liu, Jin; Chen, Jianjun Journal: JOURNAL OF MEDICINAL CHEMISTRY. 2023; Vol. 66, Issue 1, pp. 627-640. DOI: 10.1021/acs.jmedchem.2c01566 PubMed DOI |
| 10. | Structural and Functional Landscape of FAD-Dependent Histone Lysine Demethylases for New Drug Discovery Author: Song, Yihui; Wang, Shu; Yu, Bin Journal: JOURNAL OF MEDICINAL CHEMISTRY. 2023; Vol. 66, Issue 1, pp. 71-94. DOI: 10.1021/acs.jmedchem.2c01324 PubMed DOI |
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