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Replication: Checkpoint tension relief

A Schuldt - Nature Reviews Molecular Cell Biology, 2011 - nature.com
The integrity of replication forks is protected by the Mec1 (mitosis entry checkpoint 1) and Rad53
checkpoint, and cells with mutations in this checkpoint accumulate aberrant, or 'reversed', forks
when exposed to hydroxyurea. The authors set out to test the hypothesis that these ...

Heart wall tension reduction apparatus and method

CJ Schweich Jr, RM Vidlund… - US Patent 7,883,539, 2011 - Google Patents
Illllllllllllllllllllllllllllllllllllllllllllllllll US007883539B2 (12) United States Patent Schweich, Jr. et al.
(io) Patent No.: (45) Date of Patent: US 7,883,539 B2 *Feb. 8, 2011 (54) HEART WALL TENSION
REDUCTION APPARATUS AND METHOD (75) Inventors: Cyril J. Schweich, Jr., Maple ...
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Oxygen tension changes the rate of migration of human skin keratinocytes in an age‐related manner

C Ross, M Alston, JR Bickenbach… - Experimental …, 2011 - Wiley Online Library
Abstract: Migration of keratinocytes to re-epithelialize wounds is a key step in dermal wound
healing. In aged human skin, wound healing rates decrease and cellular damage by reactive
oxygen species (ROS) accumulates. The relationship between age, ROS and human skin ...
Cited by 2 - Related articles - All 4 versions

A tension-induced mechanotransduction pathway promotes epithelial morphogenesis

H Zhang, F Landmann, H Zahreddine, D Rodriguez… - Nature, 2011 - nature.com
Mechanotransduction refers to the transformation of physical forces into chemical signals. It generally
involves stretch-sensitive channels or conformational change of cytoskeleton-associated proteins
1 . Mechanotransduction is crucial for the physiology of several organs and for cell ...
Cited by 4 - Related articles - All 5 versions

Actomyosin-generated tension controls the molecular kinetics of focal adhesions

H Wolfenson, A Bershadsky, YI Henis… - Journal of Cell …, 2011 - jcs.biologists.org
Focal adhesions (FAs) have key roles in the interaction of cells with the extracellular matrix
(ECM) and in adhesion-mediated signaling. These dynamic, multi-protein structures sense the
ECM both chemically and physically, and respond to external and internal forces by ...
Cited by 2 - Related articles - All 3 versions

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