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Formation of Nucleobases and Other Prebiotic Species from the UV Irradiation of Pyrimidine in Astrophysical Ices

M Nuevo, SA Sandford, SN Milam… - IAU …, 2011 - adsabs.harvard.edu
Nucleobases are N-heterocycles which are the informational subunits of DNA and RNA. Biological
nucleobases are divided in two types: pyrimidine bases (uracil, cytosine, and thymine) and purine
bases (adenine and guanine). Nucleobases have been detected in meteorites and their ...

Dynamics and mechanism of cyclobutane pyrimidine dimer repair by DNA photolyase

Z Liu, C Tan, X Guo, YT Kao, J Li… - Proceedings of the …, 2011 - National Acad Sciences
Photolyase uses blue light to restore the major ultraviolet (UV)-induced DNA damage, the cyclobutane
pyrimidine dimer (CPD), to two normal bases by splitting the cyclobutane ring. Our earlier studies
showed that the overall repair is completed in 700 ps through a cyclic electron-transfer ...

Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis

HH Hoffmann, A Kunz, VA Simon… - Proceedings of the …, 2011 - National Acad Sciences
Compound A3 was identified in a high-throughput screen for inhibitors of influenza virus
replication. It displays broad-spectrum antiviral activity, and at noncytotoxic concentrations it
is shown to inhibit the replication of negative-sense RNA viruses (influenza viruses A and ...
Cited by 1 - Related articles - All 3 versions

Allosteric modulation of purine and pyrimidine receptors.

KA Jacobson, ZG Gao, A Göblyös… - … in pharmacology (San …, 2011 - ncbi.nlm.nih.gov
Among the purine and pyrimidine receptors, the discovery of small molecular allosteric modulators
has been most highly advanced for the A(1) and A(3) adenosine receptors (ARs). These AR
modulators have allosteric effects that are structurally separated from the orthosteric ...
Cited by 1 - Related articles - All 2 versions

Rim2, pyrimidine nucleotide exchanger, is needed for iron utilization in mitochondria.

H Yoon, Y Zhang, J Pain, ER Lyver… - The Biochemical …, 2011 - ncbi.nlm.nih.gov
Mitochondria transport and utilize iron for the synthesis of heme and Fe-S clusters. Although
many proteins are known to be involved in these processes, additional proteins are likely to
participate. To test this hypothesis, we used a genetic screen looking for yeast mutants ...

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