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Molecular Modulation of In Vivo Tolerance

CE Inturrisi… - The Opiate Receptors, 2011 - Springer
... 441 16 Molecular Modulation of In Vivo Tolerance adaptation known as pharmacodynamic
tolerance. Tolerance to opioids is predominantly of the pharmacodynamic type. ... Opioid tolerance
is predominantly of the pharmacological nonassociative and pharmacodynamic type. ...
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Population analysis of erlotinib in adults and children reveals pharmacokinetic characteristics as the main factor explaining tolerance particularities in children

M White-Koning, E Civade, B Geoerger… - Clinical Cancer …, 2011 - AACR
... Analysis of Erlotinib in Adults and Children Reveals Pharmacokinetic Characteristics as the Main
Factor Explaining Tolerance Particularities in ... Purpose: The aim of this pharmacokinetic–
pharmacodynamic (PK–PD) analysis was to evaluate the pharmacologic characteristics of ...
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Tolerance to desvenlafaxine in rapid metabolizing depressed patients

GB Parker, HL Brotchie… - International clinical …, 2011 - journals.lww.com
... pharmacokinetic tolerance' (where alterations in absorption, distribution, biotransformation or
drug elimination lead to a reduced concentration of the drug acting at its target site as a
consequence of earlier or ongoing exposure) and 'pharmacodynamic tolerance', where there ...
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A Framework for the Specificity of Addictions

[PDF] from mdpi.comS Sussman, A Leventhal, RN Bluthenthal… - International Journal of …, 2011 - mdpi.com
... has broadened in scope from referring to only physiologic processes related to drug
misuse (pharmacodynamic tolerance and withdrawal) to a more elaborate
biopsychosocial syndrome with commonalities across several behaviors. ...

[PDF] Deteriorating Cost-Benefit Ratios for Ecstasy/MDMA with Repeated Usage

[PDF] from benthamscience.comA O'Sullivan… - Open Addiction Journal, 2011 - benthamscience.com
... in mood reactions to MDMA [3-5], and the adverse mood states afterwards [6]. The universal
decline in positive ratings with repeated Ecstasy, was consistent with previous reports of decline
in efficacy [7], and is consistent with chronic pharmacodynamic tolerance [8]. The only ...
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