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Quality of Life, Needs, and Interest Among Cocaine Users: Differences by Cocaine Use Intensity and Lifetime Severity of Addiction to Cocaine

CC Morales-Manrique, A Palepu… - Substance Use & …, 2011 - informahealthcare.com
We examined the quality of life (QoL) of 149 patients who were recruited in 2005 at outpatient
treatment centers for cocaine dependence in Spain. Important life areas and life areas with potential
need and interest to change in order to improve the QoL were analyzed in terms of ...
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Chronic cocaine self-administration attenuates the anxiogenic-like and stress potentiating effects of the benzodiazepine inverse agonist, FG 7142.

RP Waters… - Pharmacology, biochemistry, and behavior, 2011 - ncbi.nlm.nih.gov
Stress is a well-known risk factor in relapse to drug abuse. Several forms of stress in animals
have been used with varied degrees of success to elicit reinstatement of drug-seeking after chronic
drug self-administration. Here, we tested the ability of the benzodiazepine (BZ) inverse ...

Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors

EP Bello, Y Mateo, DM Gelman, D Noaín… - Nature …, 2011 - nature.com
Dopamine (DA) D 2 receptors expressed in DA neurons (D 2 autoreceptors) exert a negative
feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D 2 receptors
are mostly expressed in postsynaptic neurons, pharmacological and genetic approaches ...
Cited by 1 - All 3 versions

Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine- …

MH James, JL Charnley, EM Levi… - … scientific journal of …, 2011 - Cambridge Univ Press
Abstract Orexinergic signalling is critical to drug relapse-like behaviour ; however, the CNS
sites(s) of action remain unknown. Two candidate brain regions are the paraventricular thalamus
(PVT) and ventral tegmental area (VTA). We assessed the effect of intra-PVT or -VTA ...
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Differentiating the rapid actions of cocaine

RA Wise… - Nature Reviews Neuroscience, 2011 - nature.com
The subjective effects of intravenous cocaine are felt almost immediately, and this immediacy
plays an important part in the drug's rewarding impact. The primary rewarding effect of cocaine
involves blockade of dopamine reuptake; however, the onset of this action is too late to ...
All 3 versions

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