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AMS method validation for quantitation in pharmacokinetic studies with concomitant extravascular and intravenous administration

G Lappin, M Seymour, G Young, D Higton… - Bioanalysis, 2011 - Future Science
A technique has emerged in the past few years that has enabled a drug's intravenous pharmacokinetics
to be readily obtained in humans without having to conduct extensive toxicology studies by this
route of administration or expend protracted effort in formulation. The technique involves ...
Cited by 2 - Related articles - All 3 versions

An AMS method to determine analyte recovery from pharmacokinetic studies with concomitant extravascular and intravenous administration

G Lappin, M Seymour, G Young, D Higton… - Bioanalysis, 2011 - Future Science
The absolute bioavailability, clearance and volume of distribution of a drug can be investigated
by administering a very low dose of the 14 C-drug intravenously along with a therapeutic nonlabeled
dose by the extravascular route (typically orally). The total drug concentration is ...
Cited by 1 - Related articles - All 3 versions

Pharmacokinetics and Pharmacodynamics of Dabigatran Etexilate, an Oral Direct Thrombin Inhibitor, With Coadministration of Digoxin

J Stangier, H Stähle, K Rathgen… - The Journal of …, 2011 - jcp.sagepub.com
... before administration of the next dose (Cpre,ss), mean resi- dence time of the analyte in the body
at steady state after oral administration (MRTpo,ss), and apparent vol- ume of distribution during
the terminal phase λz at steady state following extravascular administration (Vz/Fss ...

[CITATION] Pharmacokinetics and Pharmacodynamics of Antimicrobials

LL Estes - Mayo Clinic Infectious Diseases Board …, 2011 - Oxford University Press, USA
Related articles - All 2 versions

Evaluation of the pharmacokinetic interaction after multiple oral doses of linagliptin and digoxin in healthy volunteers

C Friedrich, A Ring, T Brand, R Sennewald… - European journal of …, 2011 - Springer
... in plasma following extra- vascular administration at steady-state (CL/Fss); the amount of analyte
eliminated from urine over the time interval t1–t2 at steady-state (Aet1Àt2,ss); the apparent vol-
ume of distribution during the terminal phase kz following an extravascular dose at ...
Cited by 6 - Related articles - All 4 versions

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