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Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: Prediction and prevention

J Szebeni, F Muggia, A Gabizon… - Advanced Drug Delivery …, 2011 - Elsevier
Some therapeutic liposomes and lipid excipient-based anticancer drugs are recognized by the
immune system as foreign, leading to a variety of adverse immune phenomena. One of them
is complement (C) activation, leading to a hypersensitivity syndrome called C activation- ...

Atomic Force Microscopy-Based Screening of Drug-Excipient Miscibility and Stability of Solid Dispersions

[HTML] from nih.govME Lauer, O Grassmann, M Siam, J Tardio… - Pharmaceutical …, 2011 - Springer
ABSTRACT Purpose Development of a method to assess the drug/ polymer miscibility and stability
of solid dispersions using a melt-based mixing method. Methods Amorphous fractured films are
prepared and characterized with Raman Microscopy in combination with Atomic Force ...
Cited by 3 - Related articles - All 5 versions

Protein-excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development

TJ Kamerzell, R Esfandiary, SB Joshi… - Advanced Drug Delivery …, 2011 - Elsevier
The purpose of this review is to demonstrate the critical importance of understanding
protein-excipient interactions as a key step in the rational design of formulations to stabilize and
deliver protein-based therapeutic drugs and vaccines. Biophysical methods used to ...

Development and Testing of Combination Drug and Hygroscopic Excipient Submicrometer Aerosols for Improved Respiratory Drug Delivery

W Longest, M Hindle… - 2011 - aaarabstracts.com
Abstract Enhanced excipient growth is a newly proposed respiratory delivery strategy in which
submicrometer or nanometer particles composed of a drug and hygroscopic excipient are delivered
to the airways in order to minimize extrathoracic depositional losses and maximize lung ...
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A novel excipient, 1-perfluorohexyloctane shows limited utility for the oral delivery of poorly water-soluble drugs

R Holm, EB Jorgensen, M Harborg… - European Journal of …, 2011 - Elsevier
The applicability of the semi-fluorinated alkane 1-perfluorohexyloctane (F6H8) as a novel excipient
in lipid based drug delivery systems was studied. Solubility studies of 11 poorly water soluble
drugs (cinnarizine, danazol, estradiol, fenofibrate, griseofulvin, halofantrine, lidocaine, ...
All 3 versions

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Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: Prediction and prevention

Atomic Force Microscopy-Based Screening of Drug-Excipient Miscibility and Stability of Solid Dispersions

Protein-excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development

Development and Testing of Combination Drug and Hygroscopic Excipient Submicrometer Aerosols for Improved Respiratory Drug Delivery

A novel excipient, 1-perfluorohexyloctane shows limited utility for the oral delivery of poorly water-soluble drugs