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CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: Implications for the pathogenesis of diabetic nephropathy

B Rooney, H O'Donovan, A Gaffney, M Browne… - FEBS letters, 2011 - Elsevier
We describe the activation of Wnt signalling in mesangial cells by CCN2. CCN2 stimulates phosphorylation
of LRP6 and GSK-3β resulting in accumulation and nuclear localisation of β-catenin, TCF/LEF
activity and expression of Wnt targets. This is coincident with decreased phosphorylation ...
Cited by 3 - Related articles - All 3 versions

Blockade of TSP1-Dependent TGF-[beta] Activity Reduces Renal Injury and Proteinuria in a Murine Model of Diabetic Nephropathy

A Lu, M Miao, TR Schoeb, A Agarwal… - The American Journal of …, 2011 - Elsevier
Transforming growth factor-β (TGF-β) is key in the pathogenesis of diabetic nephropathy. Thrombospondin
1 (TSP1) expression is increased in diabetes, and TSP1 regulates latent TGF-β activation in
vitro and in diabetic animal models. Herein, we investigate the effect of blockade of TSP1- ...
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341 Complications of Chronic Kidney Disease (CKD) by Level of Albuminuria and Proteinuria in the Irbesartan in Diabetic Nephropathy Trial (IDNT)

G Viswanathan, H Tighiouart… - American Journal of …, 2011 - urologyaccess.org
« PreviousNext »American Journal of Kidney Diseases Volume 57, Issue 4 , Page B102, April
2011. 341 Complications of Chronic Kidney Disease (CKD) by Level of Albuminuria and
Proteinuria in the Irbesartan in Diabetic Nephropathy Trial (IDNT). Gautham Viswanathan*: ...
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A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy

[HTML] from pnas.orgCH Wang, F Li, S Hiller, HS Kim… - Proceedings of the …, 2011 - National Acad Sciences
Polymorphisms in the human endothelial nitric oxide synthase (eNOS) gene (NOS3) have been
associated with advanced nephropathy in diabetic patients and with decreased expression in
tissue culture. However, direct proof that modest genetic decreases in eNOS expression ...
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[HTML] mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

[HTML] from nih.govK Inoki, H Mori, J Wang, T Suzuki… - The Journal of clinical …, 2011 - ncbi.nlm.nih.gov
1 Life Sciences Institute, 2 Department of Molecular and Integrative Physiology, and 3 Division
of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor,
Michigan, USA. 4 Biozentrum, University of Basel, Basel, Switzerland. 5 Translational ...
Cited by 3 - Related articles - All 4 versions

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