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Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

[HTML] from nih.govM Jin, N Shepardson, T Yang… - Proceedings of the …, 2011 - National Acad Sciences
Alzheimer disease is a major cause of cognitive failure, and a pathogenically related but more
subtle process accounts for many cases of mild memory symptoms in older humans. Insoluble
fibrillar plaques of amyloid β-proteins (Aβ) and neurofibrillary deposits of ...
Cited by 13 - Related articles - All 5 versions

Cancer and neurologic degeneration in xeroderma pigmentosum: long term follow-up characterises the role of DNA repair

PT Bradford, AM Goldstein, D Tamura… - Journal of medical …, 2011 - jmg.bmj.com
Results In the 65 per cent (n=69) of patients with skin cancer, non-melanoma skin cancer
(NMSC) was increased 10 000-fold and melanoma was increased 2000-fold in patients under
age 20. The 9 year median age at diagnosis of first non-melanoma skin cancer (NMSC) ...
Cited by 5 - Related articles - All 4 versions

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

H Kaneko, S Dridi, V Tarallo, BD Gelfand… - Nature, 2011 - nature.com
Geographic atrophy (GA), an untreatable advanced form of age-related macular
degeneration, results from retinal pigmented epithelium (RPE) cell degeneration. Here we show
that the microRNA (miRNA)-processing enzyme DICER1 is reduced in the RPE of ...
Cited by 6 - Related articles - All 5 versions

Quantification of Fluorescein-Stained Drusen Associated With Age-Related Macular Degeneration

D Friedman, JS Parker, JA Kimble, FÇC Delori… - RETINA, 2011 - journals.lww.com
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Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration

[PDF] from blind.isK Zhang, JJ Hopkins, JS Heier… - Proceedings of the …, 2011 - National Acad Sciences
There is no treatment available for vision loss associated with advanced dry age-related macular
degeneration (AMD) or geographic atrophy (GA). In a pilot, proof of concept phase 2 study, we
evaluated ciliary neurotrophic factor (CNTF) delivered via an intraocular encapsulated ...
Cited by 3 - Related articles - All 4 versions

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