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Structural Basis of Defects in the Sacsin HEPN Domain Responsible for Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS)

G Kozlov, AY Denisov, M Girard, MJ Dicaire… - Journal of Biological …, 2011 - ASBMB
... The C terminus of the protein contains an HEPN (higher eukaryotes and prokaryotes
nucleotide-binding) domain of unknown function. Here, we determined the high-resolution
1.9-Å crystal structure of the HEPN domain from human sacsin. ...
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Mycobacterial ubiquitin-like protein ligase PafA follows a two-step reaction pathway with a phosphorylated Pup intermediate

E Guth, M Thommen… - Journal of Biological Chemistry, 2011 - ASBMB
... oxygen and nitrogen species deployed by macrophages (6). The M. tuberculosis proteasomal
system plays a critical role in bacterial resistance to reactive nitrogen species both in vitro and
in vivo (7) and makes use of a ubiquitin-like molecule, termed Pup (prokaryotic ubiquitin ...
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Evolutionary Works and Texts: Reading Dobzhansky in an Age of Genomics

MP Cohen - Configurations, 2011 - muse.jhu.edu
... Barnes and Dupré argue that "[p]rokaryotes are overwhelmingly the most common organisms,
and for 80% of the history of life on the planet were the only organisms, so it would be entirely
appropriate for a discussion of genomes to take prokaryotic genomes as paradigms." 20 ...

TADB: a web-based resource for Type 2 toxin–antitoxin loci in bacteria and archaea

[HTML] from nih.govY Shao, EM Harrison, D Bi, C Tai, X He… - Nucleic Acids …, 2011 - Oxford Univ Press
... Gura_2470 (Figure 1D). The putative toxin protein (yet to be experimentally characterized),
Gura_2470, contains a MNT (minimal nucleotidyltransferase) domain, while its cognate putative
antitoxin, Gura_2469, harbors a HEPN (higher eukaryotes and prokaryotes nucleotide ...
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南美白对虾养殖底泥中氨氧化细菌与氨氧化古菌多态性分析

高利海… - ACTA MICROBIOLOGICA SINICA, 2011 - 万方数据资源系统
... Sehleper C.Jurgens G.Jonuscheit M Genomic studies of uncultivated archaea 2005(6); Leininger
S.Urich T.Schloter M.Schwark L Qi Nicol GW Prosser JI Schuster SC Schleper C Archaea
predominate among ammonia-oxidizing p rokaryotes in soils 2006(1038); ...
All 2 versions

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