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Targeting mutant fibroblast growth factor receptors in cancer

H Greulich… - Trends in Molecular Medicine, 2011 - Elsevier
... Fibroblast growth factor receptors (FGFRs) play diverse roles in the control of cell proliferation ...
Many of these somatic mutations are gain-of-function and oncogenic and create ... in preclinical
models has further substantiated genomically altered FGFR as a therapeutic target in ...
Related articles - All 2 versions

… Overexpression of Platelet-Derived Growth Factor Receptor-Beta (PDGFR-β) is Associated With PDGFRB Gene Copy Number Gain in Sarcomatoid Non-Small-Cell …

AS Tsao, W Wei, E Kuhn, L Spencer… - Clinical lung …, 2011 - ncbi.nlm.nih.gov
... Immunohistochemical Overexpression of Platelet-Derived Growth Factor Receptor-Beta
(PDGFR-β) is Associated With ... high PDGFR-β IHC expression and gene copy number gain in
sarcomatoid ... are warranted to determine whether PDGFR-β is a feasible therapeutic target in ...
All 2 versions

IBD: Adalimumab for ulcerative colitis—is the glass half empty or half full?

A Armuzzi, D Pugliese - Nature Reviews Gastroenterology and …, 2011 - nature.com
... Adalimumab is an anti-tumor necrosis factor (TNF) agent that has been shown to be effective
for both inducing and maintaining remission in moderately to severely active Crohn's disease. ...
Therefore, therapeutic gain of adalimumab over placebo was only 9.3%. ...
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… FOR MORE THAN ONE YEAR IN THE SUBSEQUENT 4 YEAR PROSPECTIVE OBSERVATIONWHAT IS THE MOST IMPORTANT FACTOR TO IMPROVE THE …

B Robinson, J Zhang, J Thumma… - NDT …, 2011 - ndtplus.oxfordjournals.org
... In this population, logistic regression analysis identified previous infection by MRSa as
the only factor associated with a higher risk of colonization. CONCLUSIONS: In this
population a significant prevalence of MRSa colonization was found. ...

The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target

[PDF] from eurobonet.euA Shalaby, N Presneau, H Ye… - The Journal of …, 2011 - Wiley Online Library
... such as activation of fibroblastic growth factor receptors or insulin-like growth factor 1 receptor ...
These data suggest that gain in HER2 copy number increases sensitivity to gefitinib of EGFR
FISH ... In theory, a similar therapeutic advantage might be expected to be afforded to the 17 ...
Cited by 3 - Related articles - All 5 versions

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