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Genesis of Phase 3 Early Afterdepolarizations and Triggered Activity in Acquired Long-QT SyndromeClinical Perspective

M Maruyama, SF Lin, Y Xie, SK Chua… - Circulation: …, 2011 - Am Heart Assoc
... of I K1 by low [K + ] o strongly promotes ventricular arrhythmias mediated by phase 3 EADs in
acquired long-QT syndrome caused by I ... in tissue are not genuine cellular-level phenomena but
are a consequence of “prolonged repolarization-dependent reexcitation.” Brugada and ...
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Refractory dispersion promotes conduction disturbance and arrhythmias in a Scn5a+/− mouse model

CA Martin, AA Grace… - Pflügers Archiv European Journal of …, 2011 - Springer
... mice have indeed shown increased repolarization gradients in the RV [27], this proposed
mechanism of early re-excitation would require ... VERP dispersion have been observed elsewhere
in experiments in genetic and pharmacological animal models of long QT syndrome [3, 18 ...

Structural heterogeneity promotes triggered activity, reflection and arrhythmogenesis in cardiomyocyte monolayers

DS Auerbach, KR Grzȩda… - The Journal of …, 2011 - Wiley Online Library
... morphology and AP duration (APD), and promotes local re-excitation during the AP plateau
(Clancy & Kass, 2005). Increased persistent I Na has been implicated as the cause of
arrhythmogenesis and sudden cardiac death, and even sudden infant death syndrome (Arnestad ...
Cited by 1 - Related articles - All 4 versions

Distinct Pharmacologic Substrate in Lidocaine-Sensitive, Repetitive Atrial Tachycardia

PA Chiale, L Faivelis, HA Garro… - Journal of …, 2011 - cpt.sagepub.com
... speculative mechanism was then proposed in which early afterdepolarizations or atrial reexcitation
due to ... of the right atrium might be due to a local re-excitation mechanism, as ... Lidocaine- sensitive,
rate-related, repetitive atrial tachycardia: a new arrhyth- mogenic syndrome. ...

The J Wave Syndromes and Their Role in Sudden Cardiac Death

D Wang, GX Yan… - Cardiac Electrophysiology Clinics, 2011 - Elsevier
... (Modified from Yan GX, Antzelevitch C. Cellular basis for the Brugada syndrome and other ... 3).
The epicardial action potential dome 35 may then propagate from epicardial sites where it is
maintained to sites at which it was lost, thus producing local re-excitation, termed “phase 2 ...
Related articles - All 3 versions

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