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Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13. 2

…, ML Drumm, PR Durie, MR Knowles, GR Cutting - Nature genetics, 2011 - nature.com
A combined genome-wide association and linkage study was used to identify loci causing variation
in cystic fibrosis lung disease severity. We identified a significant association (P = 3.34 × 10
−8 ) near EHF and APIP (chr11p13) in p.Phe508del homozygotes (n = 1,978). The ...
Cited by 1 - Related articles - All 4 versions

Immunization with Bacillus Spores Expressing Toxin A Peptide Repeats Protects against Infection with Clostridium difficile Strains Producing Toxins A and B

…, J Cook, NF Fairweather, SM Cutting - Infection and …, 2011 - Am Soc Microbiol
Clostridium difficile is a leading cause of nosocomial infection in the developed world. Two
toxins, A and B, produced by most strains of C. difficile are implicated as virulence factors, yet
only recently has the requirement of these for infection been investigated by genetic ...
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Location and Duration of Treatment of Cystic Fibrosis Respiratory Exacerbations

JM Collaco, DM Green, GR Cutting… - American Journal of …, 2011 - Am Thoracic Soc
From the Authors: The title of our article, although perhaps provocative, was intended to draw
attention to and foster debate concerning optimal treat- ment for cystic fibrosis (CF) respiratory
exacerbations to better serve patients with CF. Respiratory exacerbations are a major ...

Cutting Edge: The Murine High-Affinity IgG Receptor FcγRIV Is Sufficient for Autoantibody-Induced Arthritis

DA Mancardi, F Jönsson, B Iannascoli… - The Journal of …, 2011 - Am Assoc Immnol
K/BxN serum-induced passive arthritis was reported to depend on the activation of mast
cells, triggered by the activating IgG receptor FcγRIIIA, when engaged by IgG1 autoantibodies
present in K/BxN serum. This view is challenged by the fact that FcγRIIIA-deficient mice ...
Cited by 2 - Related articles - All 4 versions

Cutting Edge: Distinct Waves of BCL6 Expression during T Follicular Helper Cell Development

D Baumjohann, T Okada… - The Journal of Immunology, 2011 - Am Assoc Immnol
T follicular helper (T FH ) cells are central to the development and regulation of T cell-dependent
humoral immune responses. The transcriptional repressor BCL6 is required for T FH
responses, but the kinetics of BCL6 protein expression in activated CD4 + T cells have ...

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