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Reconstitution of DNA repair synthesis in vitro and the role of polymerase and helicase activities

M Sebesta, P Burkovics, L Haracska… - DNA repair, 2011 - Elsevier
... Fig. 1, lane 16). To test the specificity of our extension assay we also used a bacterial
polymerase (Klenow fragment). As shown in Supplementary Fig. ... 1, lanes 3–6). 3.2.
Pol δ–PCNA interaction is essential for repair synthesis. To ...
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PREDICTIVE VALUE OF NUCLEAR EXCISION REPAIR GENES FOR CANCER SURVIVAL

GR Simon… - US Patent 20,110,143,361, 2011 - freepatentsonline.com
... which is followed by synthesis of an intact strand through DNA polymerase activity (repair
synthesis). ... is ERCC1, and wherein patients with relatively low expression of the DNA repair
mechanism are ... 100 (62.1 months) and >100 (94.6 months)(p=0.03) (two-sided Log Rank Test). ...
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Smooth Muscle Cell Apoptosis Promotes Vessel Remodeling and Repair via Activation of Cell Migration, Proliferation, and Collagen Synthesis

H Yu, MCH Clarke, N Figg… - … and Vascular Biology, 2011 - Am Heart Assoc
... Multiple groups were compared using ANOVA followed by the Tukey test using GraphPad ... release
of factors that promote VSMC proliferation, migra- tion, and matrix synthesis. ... apoptosis occurring
after flow reduction actively promotes neointimal formation and artery repair. ...

[HTML] Underexpression of mitochondrial-DNA encoded ATP synthesis-related genes and DNA repair genes in systemic lupus erythematosus

[HTML] from arthritis-research.comHM Lee, H Sugino, C Aoki… - Arthritis research & …, 2011 - arthritis-research.com
... Conclusions. Functional abnormalities in ATP synthesis and DNA repair are implicated in ... Statistical
analysis. The unpaired Mann-Whitney test was used to determine statistically significant
differences in the mRNA expression levels between the SLE and healthy groups. ...
Cited by 1 - Related articles - Cached - All 8 versions

Apoptosis induced by persistent single-strand breaks in the mitochondrial genome: Critical role of EXOG (5′ EXO/Endonuclease) in their repair

AW Tann, I Boldogh, G Meiss, W Qian… - Journal of Biological …, 2011 - ASBMB
... consistently observed 2nt reaction products (Fig.4E,F). In addition, we performed DNA repair
synthesis assay with ... or EXOG-specific siRNA and shown that the loss of full-length repair product
with ... To test this further, we utilized A549 cells in which the mtDNA was depleted to an ...

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