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… -related behavior observed during clinical studies involving patients taking chronic opioid therapy for persistent pain and fentanyl buccal tablet for breakthrough pain

SD Passik, J Messina, A Golsorkhi… - Journal of pain and symptom …, 2011 - Elsevier
Data from opioid-tolerant patients participating in clinical studies of fentanyl buccal tablet
(FBT) for breakthrough pain (up to 18 months of clinical study case-report forms) were retrospectively
reviewed and coded for abuse, overdose, and aberrant behavior. Aberrant behaviors ...
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Fentanyl Buccal Tablets for Breakthrough Pain in Highly Tolerant Cancer Patients: Preliminary Data on the Proportionality Between Breakthrough Pain Dose and …

S Mercadante, P Ferrera, C Adile… - Journal of Pain and …, 2011 - Elsevier
Twelve patients who were receiving opioids for background analgesia at doses equivalent to
more than 500 mg of oral morphine and had adequately controlled pain were prospectively
recruited. BTcP was treated with proportional doses of FBT: patients receiving 600 mg of ...
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Assessment of the Relative Potency of Fentanyl Buccal Tablet to Intravenous Morphine in Healthy Volunteers Using a Thermally Induced Hyperalgesia Pain Model

DL Saunders, J Messina, M Darwish… - The Journal of …, 2011 - jcp.sagepub.com
It is generally accepted that the relative potency of opioids can be calculated to allow rational
dose con- versions. The potency of an opioid analgesic is typi- cally expressed relative to intravenous
(IV) morphine and can be determined using experimental clinical pharmacology models ...
Cited by 1 - Related articles - All 3 versions

Buccal tablets containing cysteine and chlorhexidine for the reduction of acetaldehyde levels in the oral cavity

C Juliano, M Cossu, MT Rota… - Drug development …, 2011 - informahealthcare.com
There is growing evidence that a large proportion of upper digestive tract tumors are ascribable
to heavy alcohol drinking and tobacco consumption. The cancer-promoting action of ethanol
is mediated by acetaldehyde, its first metabolite, also derived from the bacterial oxidation ...
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Long-term dosing, safety, and tolerability of fentanyl buccal tablet in the management of noncancer-related breakthrough pain in opioid-tolerant patients

SR Nalamachu, A Narayana… - … Medical Research & …, 2011 - informahealthcare.com
Of 1160 patients who received ≥1 dose of FBT, 83% achieved a successful dose, ranging from
100 to 800 μg, mostly at 600 or 800 μg. Not all of the patients included in this analysis were enrolled
in long-term studies and 156 (13%) patients were still receiving ongoing treatment when ...
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