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5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming

M Wossidlo, T Nakamura, K Lepikhov… - Nature …, 2011 - nature.com
... Figure 3: 5hmC in somatic cell nuclear transfer (SCNT) derived one-cell embryos. Representative
images of 2, 6 and 12 h post-activation (hpa; early G1-, late G1- and early G2-phase, see ref. ... VZ
provided rabbit and bovine zygotes and MB provided cloned one-cell embryos. ...
Cited by 8 - Related articles - All 5 versions

Single-cell tech primer

M Leslie - Science, 2011 - sciencemag.org
... But with microfluidic chips, researchers can make the same measurements on one
cell. Take ... Another new technology, known as RNA-seq, provides an alternative to
microfluidic chips for measuring gene activity in one cell. An ...
Cited by 4 - Related articles - All 4 versions

Mapping and analysis of chromatin state dynamics in nine human cell types

[PDF] from cornell.eduJ Ernst, P Kheradpour, TS Mikkelsen, N Shoresh… - Nature, 2011 - nature.com
... For most clusters, several cell types show strong (dark red) or moderate (light red) activity. b,
Analogous clustering and functional enrichments for strong enhancer state 4 (yellow). Enhancer
states show greater cell type specificity, with most clusters active in only one cell type. ...
Cited by 9 - Related articles - All 9 versions

Genetic hyperthyroidism: hyperthyroidism due to activating TSHR mutations

[HTML] from eje.orgA Hebrant, WCG van Staveren, C Maenhaut… - European Journal of …, 2011 - eje.org
... A similar pathophysiology between autonomous adenomas (AAs; (benign hyperfunctioning
tumor)). Owing to mutations (mostly TSHR), activating the TSH–cAMP cascade affects one
cell clonally expanded in an adenoma or nonencapsulated nodule. ...
Cited by 4 - Related articles - All 8 versions

The RWP-RK Factor GROUNDED Promotes Embryonic Polarity by Facilitating YODA MAP Kinase Signaling

S Jeong, TM Palmer… - Current Biology, 2011 - Elsevier
... In a strong synthetic interaction, grd;wox8;wox9 triple mutants arrest as zygotes or one-cell
embryos lacking apparent polarity. Conclusions. ... Wild-type, grd-3/grd-3, grd-4/grd-4, yda-1/+
a, One-cell stage, <1%, 1%, 1%, 2%, Two-cell stage, <1%, 5%, 2%, 17%, ...
Cited by 1

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