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[HTML] Single-Tissue and Cross-Tissue Heritability of Gene Expression Via Identity-by-Descent in Related or Unrelated Individuals

[HTML] from plos.orgAL Price, A Helgason, G Thorleifsson, SA McCarroll… - PLoS genetics, 2011 - dx.plos.org
An important goal in biology is to understand how genotype affects gene expression. Because
gene expression varies across tissues, the relationship between genotype and gene expression
may be tissue-specific. In this study, we used heritability approaches to study the ...
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A fast, powerful method for detecting identity by descent

BL Browning… - The American Journal of Human Genetics, 2011 - Elsevier
We present a method, fastIBD, for finding tracts of identity by descent (IBD) between pairs of
individuals. FastIBD can be applied to thousands of samples across genome-wide SNP data
and is significantly more powerful for finding short tracts of IBD than existing methods for ...
Cited by 5 - Related articles - All 2 versions

Identity-by-descent filtering of exome sequence data for disease–gene identification in autosomal recessive disorders

[HTML] from nih.govC Rödelsperger, P Krawitz, S Bauer, J Hecht… - …, 2011 - Oxford Univ Press
Motivation: Next-generation sequencing and exome-capture technologies are currently revolutionizing
the way geneticists screen for disease-causing mutations in rare Mendelian disorders.
However, the identification of causal mutations is challenging due to the sheer number of ...
Cited by 1 - Related articles - All 8 versions

Pedigree reconstruction using identity by descent

[PDF] from psu.eduB Kirkpatrick, S Li, R Karp… - Research in Computational …, 2011 - Springer
Abstract. Can we find the family trees, or pedigrees, that relate the haplotypes of a group of
individuals? Collecting the genealogical infor- mation for how individuals are related is a very
time-consuming and expensive process. Methods for automating the construction of pedi- ...
Cited by 1 - Related articles - All 10 versions

High-Resolution Identity by Descent Mapping Uncovers the Genetic Basis for Blood Pressure Differences Between Spontaneously Hypertensive Rat LinesClinical …

R Bell, SM Herring, N Gokul, M Monita… - Circulation: …, 2011 - Am Heart Assoc
Methods and Results—We compared genotypes at nearly 10 000 SNPs obtained for the hypertension
end-organ injury-susceptible spontaneously hypertensive rat (SHR)-A3 (SHRSP, SHR-stroke
prone) line and the injury-resistant SHR-B2 line. This revealed that that the 2 lines were ...
Related articles - All 3 versions

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