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Rapid Identification of a Disease Allele in Mouse Through Whole Genome Sequencing and Bulk Segregation Analysis

CN Arnold, Y Xia, P Lin, C Ross… - Genetics, 2011 - Genetics Soc America
In a pedigree of C57BL/6J mice homozygous for germline mutations induced by the mutagen
N-ethyl-N-nitrosourea (ENU), numerous animals died under specific pathogen-free (SPF) conditions
between 6 and 7 months of age. Death was caused by nephritic syndrome, which ...
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Segregation Analysis of Blood Pressure and Body Mass Index in a Rural US Community

SK Nath, A Chakravarti, CH Chen… - Human …, 2011 - digitalcommons.wayne.edu
To assess evidence for a gene with large effect on systolic blood pressure (SBP), diastolic blood
pressure (DBP), and body mass index (BMI), we conducted segregation analyses on 261 nuclear
families collected from a rural Caucasian community in Michigan. The families were ...
Cached - All 2 versions

Segregation Analysis of Overweight Body Condition in an Experimental Cat Population

T Häring, B Wichert, G Dolf… - Journal of Heredity, 2011 - Am Genetic Assoc
The goal of this study was to analyze the mode of inheritance of an overweight body condition
in an experimental cat population. The cat population consisted of 95 cats of which 81 cats could
be clearly classified into lean or overweight using the body condition scoring system ...

Meiotic segregation of complex reciprocal translocations: direct analysis of the spermatozoa of at (5; 13; 14) carrier

F Pellestor, J Puechberty, A Weise, G Lefort… - Fertility and Sterility, 2011 - Elsevier
... complex rearrangement in gametes. We present the results of a complete segregation
analysis performed on sperm from a man heterozygous for a complex 3-breakpoint
translocation t(5;13;14)(q23;q21;q31). We also used a ...
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der (4) t (Y; 4): Three‐generation transmission and sperm meiotic segregation analysis

M Vozdova, V Horinova… - American Journal of …, 2011 - Wiley Online Library
We present a family where five members (three males and two females) are carriers of
der(4)t(Y;4)(q11.23;p16.3). The adult carriers are phenotypicaly normal and fertile; the boy shows
macrocephaly, psychomotor retardation, and atypical autism. The FISH on cultured ...
Related articles - All 3 versions

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