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Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor

S Ruf, O Symmons, VV Uslu, D Dolle, C Hot… - Nature genetics, 2011 - nature.com
We present here a Sleeping Beauty–based transposition system that offers a simple and efficient
way to investigate the regulatory architecture of mammalian chromosomes in vivo. With this
system, we generated several hundred mice and embryos, each with a regulatory sensor ...
All 4 versions

Transposon Silencing of Small RNAs.

W Theurkauf - Developmental cell, 2011 - ncbi.nlm.nih.gov
1. Dev Cell. 2011 Aug 16;21(2):e3. Transposon Silencing of Small RNAs. Theurkauf W. ... In 2003,
miRNAs and siRNAs were known to silence target mRNAs, but small RNAs had not been directly
linked to transposon control. In August of that year, Aravin et al. ...

Manipulating piggyBac Transposon Chromosomal Integration Site Selection in Human Cells

C Kettlun, DL Galvan, AL George Jr, A Kaja… - Molecular …, 2011 - nature.com
The ability to direct gene delivery to a user-defined chromosomal location would greatly improve
gene transfer applications. The piggyBac transposon system is a nonviral gene transfer system
proven effective in a variety of cells and tissues, including human cells. We fused a highly ...
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A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis

TK Starr, PM Scott, BM Marsh… - Proceedings of the …, 2011 - National Acad Sciences
It is proposed that a progressive series of mutations and epigenetic events leads to human colorectal
cancer (CRC) and metastasis. Furthermore, data from resequencing of the coding regions of
human CRC suggests that a relatively large number of mutations occur in individual ...
Cited by 2 - Related articles - All 3 versions

Transposon Tn 5393 e Carrying the aphA1-Containing Transposon Tn 6023 Upstream of strAB Does Not Confer Resistance to Streptomycin

AK Cain… - Microbial Drug Resistance, 2011 - liebertonline.com
The simplest form of transposon Tn 5393 carries the strA and strB genes that confer
resistance to streptomycin, in addition to its transposition determinants. Tn 5393 e, made up
of Tn 5393 and a second transposon, Tn 6023, was found in an IncHI2 plasmid, pSRC125 ...
Related articles - All 2 versions

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