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Use of monoclonal antibodies to distinguish protein conformational isoforms

C Korth… - US Patent 7,932,043, 2011 - Google Patents
... 276(20): 16711-16719.* Krasemann, S., et al. "Induction of Antibodies against Human Prion
Proteins (PrP) by DNA-mediated Immunization of PrP0/0 Mice" J. Immunolog. ... "Biogenesis and
Transmembrane Orientation of the Cellular Isoform of the Scrapie Prion Protein" Mol. Cell. ...
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Cellular prion proteins in human platelets show a phenotype different to those in brain tissues

T Kuczius, J Kleinert, H Karch… - Journal of cellular …, 2011 - Wiley Online Library
... Cellular prion proteins of plt isolated from human blood were analyzed by immunoblotting with ...
Plt PrP C revealed three characteristic protein bands detected with all antibodies which ... band
with the lowest molecular mass represents the non-glycosylated isoform, whereas the ...
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HEPES inhibits the conversion of prion protein in cell culture

K Delmouly, M Belondrade… - Journal of General …, 2011 - Soc General Microbiol
... medium alone, we observed a significant inhibitory effect on accumulation of the abnormal isoform
of the ... labelled overnight at 4 °C in PBS with SAF32 antibody to detect PrP C on ... Cell lines that
are chronically infected with prions, as well as cultures expressing variable amounts ...
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Biological Effects and Use of PrPSc-and PrP-Specific Antibodies Generated by Immunization with Purified Full-Length Native Mouse Prions

B Petsch, A Muller-Schiffmann, A Lehle… - Journal of …, 2011 - Am Soc Microbiol
... Prions (PrP Sc ), the abnormal conformational isoforms of the cellular prion protein (PrP C ), are
responsible for invariably fatal neurodegenerative diseases of humans and animals (1, 35). ... 1986.
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene. ...
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Is PrP the road to ruin&quest

KA Barton… - The EMBO Journal, 2011 - nature.com
... misfolded proteins trigger cell death pathways is largely unknown, but some reports have
suggested mediation by normal cellular prion protein (PrP ... During prion diseases, PrP C is
converted to an abnormal autocatalytic isoform, PrP Sc , which can accumulate in diffuse deposits ...

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