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Sheep with scrapie and mastitis transmit infectious prions through the milk

C Ligios, MG Cancedda, A Carta… - Journal of …, 2011 - Am Soc Microbiol
Prions are misfolded proteins that are infectious and naturally transmitted, causing a fatal neurological
disease in humans and animals. Prion shedding routes have been shown to be modified by
inflammation in excretory organs, such as the kidney. Here, we show that sheep with ...
Cited by 1 - Related articles - All 4 versions

Microsecond Unfolding Kinetics of Sheep Prion Protein Reveals an Intermediate that Correlates with Susceptibility to Classical Scrapie.

KC Chen, M Xu, WJ Wedemeyer… - Biophysical journal, 2011 - ncbi.nlm.nih.gov
The microsecond folding and unfolding kinetics of ovine prion proteins (ovPrP) were measured
under various solution conditions. A fragment comprising residues 94-233 of the full-length ovPrP
was studied for four variants with differing susceptibilities to classical scrapie in sheep. ...

Effect of Glycans and the Glycophosphatidylinositol Anchor on Strain Dependent Conformations of Scrapie Prion Protein: Improved Purifications and Infrared Spectra

GS Baron, AG Hughson, GJ Raymond… - Biochemistry, 2011 - ACS Publications
Mammalian prion diseases involve conversion of normal prion protein, PrPC, to a
pathological aggregated state (PrPres). The three-dimensional structure of PrPres is not
known, but infrared (IR) spectroscopy has indicated high, strain-dependent β-sheet ...
Cited by 2 - Related articles - All 2 versions

[HTML] Th2-polarised PrP-specific Transgenic T-cells Confer Partial Protection against Murine Scrapie

[HTML] from plos.orgS Iken, V Bachy, P Gourdain, A Lim, S Grégoire… - PLoS Pathogens, 2011 - dx.plos.org
It is generally accepted that prion-specific antibodies can protect against mouse scrapie
infection. However, passive antibody therapy is limited to the lymphoinvasion stage of the
disease. Active immunization has been attempted but the results have been ...
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[HTML] Atypical/Nor98 scrapie infectivity in sheep peripheral tissues

[HTML] from plos.orgO Andréoletti, L Orge, SL Benestad, V Beringue… - PLoS Pathogens, 2011 - dx.plos.org
Following the bovine spongiform encephalopathy (BSE) crisis and the identification of its zoonotic
properties, a sanitary policy has been implemented based on both eradication of transmissible
spongiform encephalopathies (TSE) in food-producing animals and exclusion of known ...
Cited by 1 - Related articles - Cached - All 4 versions

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