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Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating

[PDF] from harvard.eduT Böcking, F Aguet, SC Harrison… - Nature Structural & …, 2011 - nature.com
Heat shock cognate protein-70 (Hsc70) supports remodeling of protein complexes, such as disassembly
of clathrin coats on endocytic coated vesicles. To understand how a simple ATP-driven molecular
clamp catalyzes a large-scale disassembly reaction, we have used single-particle ...
Cited by 2 - All 8 versions

Complementary assays reveal a relationship between HIV-1 uncoating and reverse transcription

AE Hulme, O Perez… - Proceedings of the …, 2011 - National Acad Sciences
During the early stages of HIV-1 replication the conical capsid composed of p24 CA protein dissociates
from the rest of the cytoplasmic viral complex by a process called uncoating. Although proper
uncoating is known to be required for HIV-1 infection, many questions remain about the ...
Cited by 2 - Related articles - All 4 versions

Uncoupling uncoating of Herpes Simplex Virus genomes from their nuclear import and gene expression

K Rode, K Dohner, A Binz, M Glass… - Journal of …, 2011 - Am Soc Microbiol
Incoming capsids of herpes simplex virus type 1 (HSV-1) enter the cytosol by fusion of the viral
envelopes with host cell membranes and use microtubules and microtubule motors for transport
to the nucleus. Upon docking to the nuclear pores, capsids release their genomes into the ...
Related articles - All 4 versions

Drifting Motions of the Adenovirus Receptor CAR and Immobile Integrins Initiate Virus Uncoating and Membrane Lytic Protein Exposure

CJ Burckhardt, M Suomalainen… - Cell Host & Microbe, 2011 - Elsevier
Viral particle binding to plasma membrane receptors elicits virus motions, recruits signaling
proteins, and triggers membrane bending and fission, finally resulting in endocytic virus
uptake. Here we analyze how human adenovirus engages its receptor coxsackievirus ...
Cited by 1

The TY3 Gag3 Spacer Controls Intracellular Condensation and Uncoating

[PDF] from arlorandall.comK Clemens, L Larsen, M Zhang… - Journal of …, 2011 - Am Soc Microbiol
Cells expressing the yeast retrotransposon Ty3 form concentrated foci of Ty3 proteins and RNA
within which virus-like particle (VLP) assembly occurs. Gag3, the major structural protein of the
Ty3 retrotransposon, is composed of capsid (CA), spacer (SP), and nucleocapsid (NC) ...
Related articles - All 6 versions

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