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A Chemotype That Inhibits Three Unrelated Pathogenic Targets: The Botulinum Neurotoxin Serotype A Light Chain, P. falciparum Malaria, and the Ebola Filovirus

I Opsenica, JC Burnett, R Gussio… - Journal of medicinal …, 2011 - ACS Publications
A 1, 7-bis (alkylamino) diazachrysene-based small molecule was previously identified as an
inhibitor of the botulinum neurotoxin serotype A light chain metalloprotease. Subsequently, a
variety of derivatives of this chemotype were synthesized to develop structure− activity ...
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Drosophila cell lines producing recombinant secretable filovirus surface glycoproteins lacking the membrane spanning domain

AT Lehrer, DE Clements… - US Patent 7,947,286, 2011 - Google Patents
Illlllllllllllllllllllllllllllllllllllllllllllllll US007947286B2 (12) United States Patent ao) Patent no.: us 7,947,286
B2 Lehrer et al. (45) Date of Patent: May 24,2011 (54) DROSOPHILA CELL LINES PRODUCING
RECOMBINANT SECRETABLE FILOVIRUS SURFACE GLYCOPROTEINS LACKING ...
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Intracellular Events and Cell Fate in Filovirus Infection

[PDF] from mdpi.comJ Olejnik, E Ryabchikova, RB Corley… - Viruses, 2011 - mdpi.com
1 Department of Microbiology, School of Medicine, Boston University, 72 East Concord
Street, Boston, MA 02118, USA; E-Mails: jolejnik@bu.edu (JO); rbcorley@bu.edu (RBC) 2 National
Emerging Infectious Diseases Laboratories Institute, Boston University, 72 East Concord ...

Genus-specific recruitment of filovirus ribonucleoprotein complexes into budding particles

L Spiegelberg, V Wahl-Jensen… - Journal of General …, 2011 - Soc General Microbiol
1 Short communication 1 Genus-specific recruitment of filovirus ribonucleoprotein complexes
into budding 2 particles 3 ... Allergy and Infectious Diseases, National Institutes of Health, Hamilton,
MT, USA 10 Running title: Recruitment of filovirus ribonucleoprotein complexes 11 12 ...

Inhibition of filovirus entry into cells and uses thereof

RA Davey, AA Kolokoltsov… - US Patent …, 2011 - freepatentsonline.com
The present invention discloses method to treat infections caused by filovirus. Such a method
comprises blocking the PI3 kinase pathway or the calcium-associated pathway at the gene or
protein level. Also disclosed herein are the compounds useful in the treatment of filoviral ...
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