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JB Bucher, MR Golden, AE Heald… - Sexually transmitted …, 2011 - journals.lww.com
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D Croisier-Bertin, L Piroth, PE Charles… - Antimicrobial Agents …, 2011 - Am Soc Microbiol
Ceftaroline (CPT) is a new cephalosporin exhibiting bactericidal activity against Gram-positive
organisms, including methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant
Streptococcus pneumoniae (MDRSP), as well as common Gram-negative pathogens. ...
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Q Shi, SO Meroueh, JF Fisher… - Journal of the American …, 2011 - ACS Publications
Penicillin-binding protein 1b (PBP 1b) of the Gram-positive bacterium Streptococcus
pneumoniae catalyzes the cross-linking of adjacent peptidoglycan strands, as a critical
event in the biosynthesis of its cell wall. This enzyme is representative of the biosynthetic ...
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R Douma, J Batista, K Touw, J Kiel… - BMC Systems …, 2011 - biomedcentral.com
During these cultivations, the biomass specific penicillin production rate decreased more than
10-fold in less than 22 generations. No evidence was obtained for a decrease of the copy number
of the penicillin gene cluster, nor a significant down regulation of the expression of the ...
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A Zervosen, R Herman, F Kerff… - Journal of the …, 2011 - ACS Publications
Boronic acids bearing appropriate side chains are good inhibitors of serine
amidohydrolases. The boron usually adopts a tetrahedral conformation, bound to the
nucleophilic serine of the active site and mimicking the transition state of the enzymatic ...
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