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Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells

[HTML] from pnas.orgRK Montgomery, DL Carlone… - Proceedings of the …, 2011 - National Acad Sciences
The intestinal epithelium is maintained by a population of rapidly cycling (Lgr5 + ) intestinal stem
cells (ISCs). It has been postulated, however, that slowly cycling ISCs must also be present in
the intestine to protect the genome from accumulating deleterious mutations and to allow ...
Cited by 11 - Related articles - All 4 versions

HBV DNA Replication Mediated by Cloned Patient HBV Reverse Transcriptase Genes from HBV Genotypes AH and Its Use in Antiviral Phenotyping Assays

Y Zhu, M Curtis… - Journal of virological methods, 2011 - Elsevier
The aim of this study is to establish a phenotyping assay to analyze patient HBV
polymerase/reverse transcriptase (RT) sequences for potential drug resistance against RT
inhibitors. HBV RT (pol aa 304 to 715, including the entire RT) from clinical isolates were ...
All 3 versions

Selection of nonnucleoside reverse transcriptase inhibitor-associated mutations in HIV-1 subtype C: evidence of etravirine cross-resistance

[PDF] from natap.orgU Neogi, A Shet, R Shamsundar… - AIDS, 2011 - journals.lww.com
The low genetic barrier to development of resistance to first generation nonnucleoside reverse
transcriptase inhibitors (NNRTIs) is compounded by cross-resistance across the class that makes
sequential therapy with the NNRTIs therapeutically inappropriate. Current first-line NNRTI ...
Related articles - All 3 versions

A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase

T Hinkley, J Martins, C Chappey, M Haddad… - Nature Genetics, 2011 - nature.com
The development of a quantitative understanding of viral evolution and the fitness landscape
in HIV-1 drug resistance is a formidable challenge given the large number of available drugs
and drug resistance mutations. We analyzed a dataset measuring the in vitro fitness of ...
Cited by 3 - Related articles - All 3 versions

A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis

W Jia, S Wang, JW Horner, N Wang, H Wang… - The FASEB Journal, 2011 - FASEB
Telomerase is tightly regulated in humans relative to mice, owing to the differential regulation
of TERT genes. To explore hTERT regulation in vivo, we engineered mice with a 160-kb transgenic
bacterial artificial chromosome (BAC) spanning the hTERT locus with a Renilla luciferase ...
Related articles - All 3 versions

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