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The Vi capsular polysaccharide prevents complement receptor 3-mediated clearance of Salmonella enterica serotype Typhi

RP Wilson, SE Winter, AM Spees… - Infection and …, 2011 - Am Soc Microbiol
Capsular polysaccharides are important virulence factors of invasive bacterial pathogens. Here
we studied the role of the virulence (Vi) capsular polysaccharide of Salmonella enterica serotype
Typhi (S. Typhi) in preventing innate immune recognition by complement. Comparison of ...
Cited by 1 - Related articles - All 4 versions

The Characterization of PrpZ and PrkY, Two Eukaryotic-Type Proteins of Salmonella enterica Serovar Typhi

PP Gros - 2011 - gradworks.umi.com
Sequencing of the S. typhi genome has allowed a better understanding of the pathogenesis
caused by this bacterium. In silico research on the genome sequence identified three open reading
frames, termed prpZ gene cluster, present in the Ty2 and multi-drug resistant CT18 strains ...
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Genomics and Pathogenesis of Salmonella enterica Serovars Typhi and Paratyphi A

KE Holt, TT Perkins, G Dougan… - … : From Genome to …, 2011 - books.google.com
6 Genomics and Pathogenesis of Salmonella enterica Serovars Typhi and Paratyphi A Kathryn
E. Holt, Tim T. Perkins, Gordon Dougan and Robert A. Kingsley* Abstract The genomics era has
transformed the way that we can study bacterial pathogens. The avail- ability of two ...
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… priming with Salmonella Typhi vaccine strain CVD 909 followed by parenteral boost with the S. Typhi Vi capsular polysaccharide vaccine induces CD27+ IgD-S. Typhi …

R Wahid, MF Pasetti, M Maciel Jr, JK Simon… - Clinical …, 2011 - Elsevier
Attenuated live oral typhoid vaccine candidate CVD 909 constitutively expresses Salmonella
Typhi capsular polysaccharide antigen (Vi). A randomized, double-blind, heterologous
prime–boost clinical study was conducted to determine whether immunity to licensed ...
Related articles - All 5 versions

Mechanism of capsule-mediated innate immune evasion by Salmonella enterica serotype Typhi

RP Wilson - 2011 - gradworks.umi.com
The viaB locus enables Salmonella enterica serotype Typhi to reduce Toll-like receptor
(TLR) dependent cytokine production in tissue culture models. This DNA region contains genes
involved in the regulation (tviA ), biosynthesis (tviBCDE ) and export (vexABCDE ) of the ...
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