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Evidence That the Thyroid-stimulating Hormone (TSH) Receptor Transmembrane Domain Influences Kinetics of TSH Binding to the Receptor Ectodomain

CR Chen, SM McLachlan… - Journal of Biological Chemistry, 2011 - ASBMB
Thyroid-stimulating hormone (TSH)-induced reduction in ligand binding affinity (negative
cooperativity) requires TSH receptor (TSHR) homodimerization, the latter involving primarily
the transmembrane domain (TMD) but with the extracellular domain (ECD) also ...
Cited by 3 - Related articles - All 2 versions

Congenital Hypothyroidism with a Delayed Thyroid-Stimulating Hormone Elevation in Very Premature Infants: Incidence and Growth and Developmental Outcomes

HC Woo, A Lizarda, R Tucker, ML Mitchell… - The Journal of …, 2011 - Elsevier
To test the hypothesis that very low birth weight (VLBW) and extremely low birth weight
(ELBW) infants have an increased incidence of congenital hypothyroidism (CH) with a delayed
thyroid-stimulating hormone (TSH) elevation and that the outcomes of these infants are ...
Cited by 2 - Related articles - All 3 versions

Functional sensitivity of seven automated thyroid stimulating hormone immunoassays

WE Owen, ML Gantzer, JM Lyons, AF Rockwood… - Clinica Chimica …, 2011 - Elsevier
The FS (mIU/l) for Access 2, ADVIA Centaur, ARCHITECT i2000, Dimension ExL,Modular Analytics
E170, Immulite 2000, and Dimension Vista 1500 systems were determined to be 0.039,
0.006, 0.007, 0.003, 0.008, 0.003, and 0.003, respectively. The lowest and next to lowest ...

Subclinical elevations of thyroid-stimulating hormone and assisted reproductive technology outcomes

KG Michalakis, TB Mesen, LM Brayboy, B Yu… - Fertility and Sterility, 2011 - Elsevier
In women of reproductive age the prevalence of overt hypothyroidism ranges from 0.4% to
0.5%, whereas the prevalence of subclinical hypothyroidism ranges from 2% to 4% (1) and
(2). Overt hypothyroidism may result in reproductive disturbances, including menstrual ...
Cited by 1 - Related articles - All 4 versions

Thyroid-stimulating hormone, 5-HTTLPR genotype, and antidepressant response in depressed women

F Gressier, S Trabado, C Verstuyft… - Psychiatric …, 2011 - journals.lww.com
Basal serum thyroid-stimulating hormone (TSH) levels may predict antidepressant efficacy in
patients with major depressive episodes (MDE), but data are inconsistent. As the SS genotype
of the 5-HTTLPR polymorphism has been associated with a lower antidepressant efficacy ...
Related articles - All 4 versions

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