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Population Pharmacokinetics of Piperacillin at Two Dose Levels: Influence of Nonlinear Pharmacokinetics on the Pharmacodynamic Profile

C Landersdorfer, C Kirkpatrick, J Bulitta… - 2006 AAPS Annual …, 2011 - aapsj.org
Population Pharmacokinetics of Piperacillin at Two Dose Levels: Influence of Nonlinear
Pharmacokinetics on the Pharmacodynamic Profile C. Landersdorfer 1, C. Kirkpatrick 2, J. Bulitta
1, M. Kinzig-Schippers 1, U. Holzgrabe 3, G. Drusano 4, F. Sörgel 1 1 IBMP, Nürnberg ...
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Rationale and evidence for extended infusion of piperacillin–tazobactam

SE Kaufman, RW Donnell… - American Journal of Health-System …, 2011 - ASHP
Summary EI β-lactam therapy is now considered a key aspect of antimicrobial stewardship, and
published evidence indicates that iv infusion of piperacillin–tazobactam over extended periods
(eg, four hours) instead of the traditionally recommended 30 minutes may offer several ...

In vitro efficiency of the piperacillin/tazobactam combination against inhibitor-resistant TEM-and complex mutant TEM-producing clinical strains of Escherichia coli

F Robin, M Krebs, J Delmas… - Journal of …, 2011 - Br Soc Antimicrob Chemo
Results Piperacillin/tazobactam was bacteriostatic against most of the tested strains (15/16).
Using a high inoculum, the piperacillin/tazobactam combination was not bactericidal against
the 13 IRT-producing strains and one of the CMT-producing strains (1/3). A loss of ...
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Therapeutic Drug Monitoring of Piperacillin-Tazobactam Using Spent Dialysate Effluent in Patients Receiving Continuous Venovenous Hemodialysis

MJ Connor Jr, C Salem, SR Bauer… - Antimicrobial Agents …, 2011 - Am Soc Microbiol
Sepsis and multisystem organ failure are common diagnoses affecting nearly three-quarters
of a million Americans annually. Infection is the leading cause of death in acute kidney
injury, and the majority of critically ill patients who receive continuous dialysis also ...
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Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis

P Whitaker, X Meng, SN Lavergne… - The Journal of …, 2011 - Am Assoc Immnol
A mechanistic understanding of the relationship between the chemistry of drug Ag formation
and immune function is lacking. Thus, mass spectrometric methods were employed to detect
and fully characterize circulating Ags derived from piperacillin in patients undergoing ...
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