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Indomethacin abolishes core temperature, but not cardiovascular or renal, responses to lipopolysaccharide in conscious lambs

FG Smith, JE Fewell… - Clinical and Experimental …, 2011 - Wiley Online Library
... 2 Following exposure to a blood-borne exogenous pyrogen such as lipopolysaccharide (LPS),
cells of the immune system synthesize and secrete endogenous pyrogens, including interleukin
(IL)-1β, IL-6 and tumour necrosis factor-α, 3 which results in the production of cyclo ...

Regarding" Change in Temperature Profile May Precede Fever and Be an Early Indicator of Sepsis: A Case Series" by Mohr et al. Shock 36: 000-000, 2011

PA Ward - Shock, 2011 - journals.lww.com
... Although exogenous pyrogens such as LPS are well known to induce fever, it is unclear if
they are responsible for induction of the prefebrile variations in temperature patterns described
in this report and featuring patients with gram-negative bacteremia. ...

Clinical and molecular aspects of malaria fever

MS Oakley, N Gerald, TF McCutchan, L Aravind… - Trends in …, 2011 - Elsevier
... IL-6, as well as complement factor 5a (C5a) and prostaglandin E 2 (PGE 2 ) [7]. Phagocytic
monocytes in peripheral tissues have been shown to be important sources of these endogenous
pyrogens in response to the exogenous pyrogens derived from pathogenic organisms. ...

Fever in the Critically Ill: A Review of Epidemiology, Immunology, and Management

DJ Niven, C Leger, HT Stelfox… - Journal of Intensive …, 2011 - jic.sagepub.com
... In this model, the exogenous pyrogen (LPS) activates mononuclear phagocytic cells to produce
endo- genous pyrogenic cytokines such as those listed in Table 1.17 These molecules are
transported via the blood to circumventri- cular organs where they cross the blood-brain ...
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ANTI-FEVER BOTANICAL COMPOSITION AND USES THEREOF

BP Srivastava… - US Patent 20,110,171,330, 2011 - freepatentsonline.com
... A pyrogen may be endogenous or exogenous to the body. The bacterial substance
lipopolysaccharide (LPS) is an example of an exogenous pyrogen and certain cytokines
produced by phagocytic cells are exemplary endogenous pyrogens. ...
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