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Primary resistance to cetuximab in a panel of patient-derived tumour xenograft models: Activation of MET as one mechanism for drug resistance

R Krumbach, J Schüler, M Hofmann… - European Journal of …, 2011 - Elsevier
Cetuximab (Erbitux®) targets the epidermal growth factor receptor (EGFR) and is approved for
treatment of colorectal and head and neck cancer. Despite wide expression of EGFR, only a
subgroup of cancer patients responds to cetuximab therapy. In the present study we ...
Cited by 1 - Related articles - All 3 versions

Co‐circulation HIV‐1 subtypes B, C, and CRF31_BC in a drug‐naïve population from Southernmost Brazil: Analysis of primary resistance mutations

RM de Medeiros, DM Junqueira… - Journal of Medical …, 2011 - Wiley Online Library
In Southernmost Brazil HIV-1 subtypes B, C, and CRF31_BC co-circulates and, since 1996 with
the implementation of free access to highly active antiretroviral treatment (HAART), this epidemic
is under a quite characteristic selective pressure. The profile of mutations and ...

[HTML] Mechanisms of Resistance to Decitabine in the Myelodysplastic Syndrome

[HTML] from plos.orgT Qin, R Castoro, S El Ahdab, J Jelinek, X Wang… - PloS one, 2011 - dx.plos.org
... Most genes showed no differences by response, but the CDA/DCK ratio was 3 fold higher in
non-responders than responders (P<.05), suggesting that this could be a mechanism of primary
resistance. ... DAC metabolism gene expression in primary resistance. ...
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[PDF] Primary and secondary clarithromycin, metronidazole, amoxicillin and levofloxacin resistance to Helicobacter pylori in southern Poland

[PDF] from krakow.plM Zwoliñska-Wcis³o… - Pharmacological Reports, 2011 - if-pan.krakow.pl
Department of Pharmaceutical Microbiology of the Jagiellonian University Medical College, Medyczna
9, PL 30-688 Kraków, Poland ... Gastroenterological Outpatient Clinic „Falck Medycyna”,
Kraków, Poland ! Chair of Gastroenterology Hepatology and Infections Diseases, ...
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EGFR and EML4-ALK gene mutations in NSCLC: A case report of erlotinib-resistant patient with both concomitant mutations

M Tiseo, F Gelsomino, D Boggiani, B Bortesi… - Lung Cancer, 2011 - Elsevier
... of acquired resistance have been identified, a secondary T790M mutation in EGFR exon 20 and
the amplification of the MET gene [2]. Furthermore, 20–30% of EGFR mutated patients do not
respond to EGFR-TKIs due to unknown mechanisms of primary resistance. ...
Cited by 3 - Related articles - All 3 versions

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