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From Rous sarcoma virus to plasminogen activator, src oncogene and cancer management

M Sudol - Oncogene, 2011 - nature.com
Plasminogen activator (PLAU) is a serine protease that converts plasminogen to plasmin, a general
protease, which promotes fibrinolysis and degradation of extracellular matrix. PLAU was reported
in 1970s as one of the robustly induced enzymatic activities in Rous sarcoma virus (RSV)- ...
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p53-paralog DNp73 oncogene is repressed by IFNα/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor

B Testoni, V Schinzari, F Guerrieri… - Oncogene, 2011 - nature.com
The DNp73 proteins act as trans-repressors of p53 and p73-dependent transcription and exert
both anti-apoptotic activity and pro-proliferative activity. DNp73s are frequently up-regulated
in a variety of human cancers, including human hepatocellular carcinomas (HCCs). ...
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Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control

H Jäkel, C Weinl… - Oncogene, 2011 - nature.com
Janus kinase 2 (JAK2) couples ligand activation of cell surface cytokine receptors to the regulation
of cellular functions including cell cycle progression, differentiation and apoptosis. It thereby
coordinates biological programs such as development and hematopoiesis. Unscheduled ...
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The human DEK oncogene stimulates β-catenin signaling, invasion and mammosphere formation in breast cancer

LMP Vinnedge, R McClaine, PK Wagh… - Oncogene, 2011 - nature.com
Breast cancer is a major cause of cancer-related deaths in American women; therefore, the identification
of novel breast cancer-related molecules for the discovery of new markers and drug targets remains
essential. The human DEK gene, which encodes a chromatin-binding protein and DNA ...
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The proto-oncogene Pim-1 is a target of miR-33a

M Thomas, K Lange-Grünweller, U Weirauch… - Oncogene, 2011 - nature.com
The constitutively active serine/threonine kinase Pim-1 is upregulated in different cancer
types, mainly based on the action of several interleukines and growth factors at the transcriptional
level. So far, a regulation of oncogenic Pim-1 by microRNAs (miRNAs) has not been ...
Cited by 1 - Related articles - All 3 versions

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