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[PDF] Common Fragile Site Tumor Suppressor Genes and Corresponding Mouse Models of Cancer

[PDF] from hindawi.comA Drusco, Y Pekarsky, S Costinean… - Lung, 2011 - downloads.hindawi.com
1 Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State
University, Columbus, OH 43210, USA 2 Clinical Pathology, Regina Elena Institute, IFO, 00144
Rome, Italy 3 Department of Immunology and Cancer Research-IMRIC, The Lautenberg ...
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Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen …

[HTML] from nih.govLV O'Keefe, A Colella, S Dayan… - Human molecular …, 2011 - Oxford Univ Press
Common chromosomal fragile sites FRA3B and FRA16D are frequent sites of DNA instability
in cancer, but their contribution to cancer cell biology is not yet understood. Genes that span
these sites (FHIT and WWOX, respectively) are often perturbed (either increased or ...
Cited by 2 - Related articles - All 7 versions

The FRA2C common fragile site maps to the borders of MYCN amplicons in neuroblastoma and is associated with gross chromosomal rearrangements in different …

A Blumrich, M Zapatka, LM Brueckner… - Human molecular …, 2011 - Oxford Univ Press
Common fragile sites (cFS) represent chromosomal regions that are prone to breakage after
partial inhibition of DNA synthesis. Activation of cFS is associated with various forms of DNA
instability in cancer cells, and is thought to be an initiating event in the generation of DNA ...
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Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

A Letessier, GA Millot, S Koundrioukoff… - Nature, 2011 - nature.com
Common fragile sites have long been identified by cytogeneticists as chromosomal regions prone
to breakage upon replication stress 1 . They are increasingly recognized to be preferential targets
for oncogene-induced DNA damage in pre-neoplastic lesions 2 and hotspots for ...
Cited by 5 - Related articles - All 5 versions

Failure of Origin Activation in Response to Fork Stalling Leads to Chromosomal Instability at Fragile Sites

E Ozeri-Galai, R Lebofsky, A Rahat, AC Bester… - Molecular Cell, 2011 - Elsevier
... Here, we show that even under normal growth conditions, replication fork progression along
the fragile site, FRA16C, is slow and forks frequently stall at AT-rich sequences, leading
to activation of additional origins to enable replication completion. ...
All 2 versions

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