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CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: Implications for the pathogenesis of diabetic nephropathy

B Rooney, H O'Donovan, A Gaffney, M Browne… - FEBS letters, 2011 - Elsevier
We describe the activation of Wnt signalling in mesangial cells by CCN2. CCN2 stimulates phosphorylation
of LRP6 and GSK-3β resulting in accumulation and nuclear localisation of β-catenin, TCF/LEF
activity and expression of Wnt targets. This is coincident with decreased phosphorylation ...
Cited by 3 - Related articles - All 3 versions

Blockade of TSP1-Dependent TGF-[beta] Activity Reduces Renal Injury and Proteinuria in a Murine Model of Diabetic Nephropathy

A Lu, M Miao, TR Schoeb, A Agarwal… - The American Journal of …, 2011 - Elsevier
Transforming growth factor-β (TGF-β) is key in the pathogenesis of diabetic nephropathy. Thrombospondin
1 (TSP1) expression is increased in diabetes, and TSP1 regulates latent TGF-β activation in
vitro and in diabetic animal models. Herein, we investigate the effect of blockade of TSP1- ...
Related articles - All 4 versions

Genome-wide association study identifies susceptibility loci for IgA nephropathy

AG Gharavi, K Kiryluk, M Choi, Y Li, P Hou… - Nature genetics, 2011 - nature.com
We carried out a genome-wide association study of IgA nephropathy, a major cause of kidney
failure worldwide. We studied 1,194 cases and 902 controls of Chinese Han ancestry, with targeted
follow up in Chinese and European cohorts comprising 1,950 cases and 1,920 controls. ...
Cited by 4 - Related articles - All 5 versions

Primary IgA Nephropathy: New Insights Into Pathogenesis

J Barratt… - Seminars in Nephrology, 2011 - Elsevier
Since its first description more than 40 years ago, IgA nephropathy has become the most common
pattern of primary glomerulonephritis identified in all areas of the world where renal biopsy is
routinely performed. This review discusses advances in our understanding of the ...

341 Complications of Chronic Kidney Disease (CKD) by Level of Albuminuria and Proteinuria in the Irbesartan in Diabetic Nephropathy Trial (IDNT)

G Viswanathan, H Tighiouart… - American Journal of …, 2011 - urologyaccess.org
« PreviousNext »American Journal of Kidney Diseases Volume 57, Issue 4 , Page B102, April
2011. 341 Complications of Chronic Kidney Disease (CKD) by Level of Albuminuria and
Proteinuria in the Irbesartan in Diabetic Nephropathy Trial (IDNT). Gautham Viswanathan*: ...
Cached - All 2 versions

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