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Alzheimer's Ab42 oligomers but not fibrils simultaneously bind to and cause damage to ganglioside containing lipid membranes.

TL Willliams, BR Johnson, B Urbanc… - The Biochemical …, 2011 - ncbi.nlm.nih.gov
Amyloid-Beta peptide (Ab) assembles to form amyloid fibres that accumulate in senile plaques
associated with Alzheimer's disease (AD). The major constituent, a 42-residue Ab peptide, has
the propensity to assemble and form soluble and potentially cytotoxic oligomers as well ...
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[PDF] Imaging Technology of Complex Lipid Molecular Species by a Combination of TLC-Blot and MALDI-TOF–Special Reference to Human Brain Ganglioside …

[PDF] from omicsonline.orgT Valdes-Gonzalez, N Goto-Inoue… - J Glycom …, 2011 - omicsonline.org
... Combination of TLC-Blot and MALDI- TOF –Special Reference to Human Brain
Ganglioside Molecular Species ... Then we analyzed ganglioside molecular species
obtained from different brain regions by using MS imaging technology. ...
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[HTML] Production of Multiple Brain-Like Ganglioside Species Is Dispensable for Fas-Induced Apoptosis of Lymphoid Cells

[HTML] from plos.orgI Popa, N Therville, S Carpentier, T Levade… - PloS one, 2011 - dx.plos.org
Activation of an acid sphingomyelinase (aSMase) leading to a biosynthesis of GD3 disialoganglioside
has been associated with Fas-induced apoptosis of lymphoid cells. The present study was undertaken
to clarify the role of this enzyme in the generation of gangliosides during apoptosis ...
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[PDF] Alzheimer's Aβ42 oligomers but not fibrils simultaneously bind to and cause damage to ganglioside containing lipid membranes

[PDF] from biochemj.orgTL Williams, BRG Johnson, B Urbanc, ATA Jenkins… - 2011 - biochemj.org
1 Alzheimer's Aβ42 oligomers but not fibrils simultaneously bind to and cause damage to
ganglioside containing lipid membranes ... Binding of the oligomers may be in part mediated by
the GM1 ganglioside receptors showing a 1.8-fold increase in oligomeric Aβ binding and a 2- ...
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Amyloid-[beta] induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action

F Kreutz, RL Frozza, AC Breier… - Neurochemistry …, 2011 - Elsevier
The effect of Aβ25–35 peptide, in its fibrillar and non-fibrillar forms, on ganglioside expression
in organotypic hippocampal slice cultures was investigated. Gangliosides were endogenously
labeled with d-[1-C 14 ] galactose and results showed that Aβ25–35 affected ganglioside ...
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