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GL Semenza - Studies on Renal Disorders, 2011 - Springer
Abstract The hypoxia-inducible factors (HIFs) are transcriptional activators that mediate homeostatic
responses to hypoxia. At the cellular level, HIF-1 mediates adaptive metabolic responses to hypoxia
that serve to maintain energy and redox homeostasis by reducing mitochondrial ...
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Y Xue, NL Li, JY Yang, Y Chen… - American Journal of …, 2011 - Am Physiological Soc
We have previously demonstrated the roles of RhoA, Rac1, and Cdc42 in hypoxia-driven
angiogenesis. However, the role of oncogenes in hypoxia signaling is poorly understood. Given
the importance of Rho proteins in the hypoxic response, we hypothesized that Rho family ...
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DJ Klemm, SM Majka, JT Crossno Jr… - Journal of …, 2011 - journals.lww.com
Hypoxia-induced pulmonary arterial hypertension (PAH) is a deadly disease characterized by
progressive remodeling and persistent vasoconstriction of the pulmonary arterial (PA)
system. Remodeling of the PA involves smooth muscle cell (SMC) proliferation, ...
All 3 versions
LA Palmer, WJ May, K deRonde… - American Journal of …, 2011 - Am Thoracic Soc
... Convention Center Ventilatory Responses During And Following Exposure To Hypoxia In
Conscious Mice Deficient Or Null In S-Nitrosoglutathione Reductase ... Exposure to hypoxia elicits
an increase in Minute Ventilation (MV) that diminishes with continued exposure (roll-off). ...
All 3 versions
WR Wilson… - Nature Reviews Cancer, 2011 - nature.com
Hypoxia is a feature of most tumours, albeit with variable incidence and severity within a given
patient population. It is a negative prognostic and predictive factor owing to its multiple contributions
to chemoresistance, radioresistance, angiogenesis, vasculogenesis, invasiveness, ...
Cited by 3 - Related articles - All 3 versions

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