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Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors

F Bosmans, M Puopolo… - The Journal of …, 2011 - jgp.rupress.org
The voltage-activated sodium (Nav) channel Nav1.9 is expressed in dorsal root ganglion
(DRG) neurons where it is believed to play an important role in nociception. Progress in revealing
the functional properties and pharmacological sensitivities of this non-canonical Nav ...
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Metallothionein promotes regenerative axonal sprouting of dorsal root ganglion neurons after physical axotomy

JYK Leung, WR Bennett, RP Herbert… - Cellular and Molecular …, 2011 - Springer
Abstract Prior studies have reported that metallothionein I/II (MT) promote regenerative axonal
sprouting and neu- rite elongation of a variety of central nervous system neurons after injury.
In this study, we evaluated whether MT is capable of modulating regenerative axon ...

Deletion mutation of sodium channel NaV1. 7 in inherited erythromelalgia: enhanced slow inactivation modulates dorsal root ganglion neuron hyperexcitability

X Cheng, SD Dib-Hajj, L Tyrrell, RH te Morsche… - Brain, 2011 - Oxford Univ Press
Gain-of-function missense mutations of voltage-gated sodium channel Na V 1.7 have been linked
to the painful disorder inherited erythromelalgia. These mutations hyperpolarize activation, slow
deactivation and enhance currents evoked by slow ramp stimuli (ramp currents). A ...
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Increased Na+ and K+ currents in small mouse dorsal root ganglion neurons after ganglion compression

N Fan, P Sikand, DF Donnelly… - Journal of …, 2011 - Am Physiological Soc
We investigated the effects of chronic compression (CCD) of the L3 and L4 dorsal root ganglion
(DRG) on pain behavior in the mouse and on the electrophysiological properties of the
small-diameter neuronal cell bodies in the intact ganglion. CCD is a model of human ...
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… of interleukin-6 to the dorsal root ganglion induces tumor necrosis factor-alpha in the dorsal root ganglion and results in apoptosis of the dorsal root ganglion cells

Y Murata, B Rydevik, U Nannmark, K Larsson… - Spine, 2011 - journals.lww.com
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