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A Cation-π Interaction at a Phenylalanine Residue in the Glycine Receptor Binding Site Is Conserved for Different Agonists

SA Pless, AP Hanek, KL Price, JW Lynch… - Molecular …, 2011 - ASPET
Cation-π interactions have been demonstrated to play a major role in agonist-binding in
Cys-loop receptors. However, neither the aromatic amino acid contributing to this interaction
nor its location is conserved among Cys-loop receptors. Likewise, it is not clear how many ...
Cited by 2 - Related articles - All 5 versions

Identification of Genes in the Phenylalanine Metabolic Pathway by Ectopic Expression of a MYB Transcription Factor in Tomato Fruit

V Dal Cin, DM Tieman, T Tohge… - The Plant Cell …, 2011 - Am Soc Plant Biol
Altering expression of transcription factors can be an effective means to coordinately modulate
entire metabolic pathways in plants. It can also provide useful information concerning the identities
of genes that constitute metabolic networks. Here, we used ectopic expression of a MYB ...

The extracellular calcium-sensing receptor is required for cholecystokinin secretion in response to l-phenylalanine in acutely isolated intestinal I cells

AP Liou, Y Sei, X Zhao, J Feng… - American Journal of …, 2011 - Am Physiological Soc
The extracellular calcium-sensing receptor (CaSR) has recently been recognized as an l-amino
acid sensor and has been implicated in mediating cholecystokinin (CCK) secretion in response
to aromatic amino acids. We investigated whether direct detection of l-phenylalanine ...
Cited by 1 - Related articles - All 4 versions

ChemInform Abstract: The Synthesis of Phenylalanine‐Derived C5‐Substituted Rhodanines and Their Activity Against Selected Methicillin‐Resistant Staphylococcus …

D Hardej, CR Ashby Jr, NS Khadtare… - …, 2011 - Wiley Online Library
Glycine and phenylalanine-derived rhodanine analogues are prepared. Hydrophobic side chains
of valine, leucine and phenylalanine, cf. (VI)), at the N-3 position and the electron-deficient benzylidene
moiety at C-5 position of the rhodanine scaffold improves the activity against MRSA. The ...

Phenylalanine hydroxylase deficiency

JJ Mitchell, YJ Trakadis… - Genetics in Medicine, 2011 - journals.lww.com
Phenylalanine hydroxylase deficiency is an autosomal recessive disorder that results in intolerance
to the dietary intake of the essential amino acid phenylalanine. It occurs in approximately 1:15,000
individuals. Deficiency of this enzyme produces a spectrum of disorders including classic ...
Cited by 5 - Related articles - All 3 versions

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