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Development of a highly sensitive cytotoxicity assay system for CYP3A4-mediated metabolic activation

H Hosomi, T Fukami, A Iwamura, M Nakajima… - Drug Metabolism and …, 2011 - ASPET
... would be associated with the hepatotoxicity, in human liver microsomes. These ... Flutamide is
reported be oxidized into reactive metabolites that covalently bind to microsomal proteins ...
investigate the drug-induced cytotoxicity mediated by CYPs, but this system generally ...
Cited by 1 - Related articles - All 2 versions

CYP2C9-Mediated Metabolic Activation of Losartan Detected by a Highly Sensitive Cell-Based Screening Assay

A Iwamura, T Fukami, H Hosomi, M Nakajima… - Drug Metabolism and …, 2011 - ASPET
... could form protein or glutathione adducts by incubation with human liver microsomes and/or ... rat
liver after oral administration, although it did not bind to microsomal protein in ... constructed a highly
sensitive cell-based assay system to evaluate CYP2C9-mediated cytotoxicity and ...
Cited by 1 - Related articles - All 4 versions

DNA adducts and oxidative DNA damage induced by organic extracts from PM2. 5 in an acellular assay

J Topinka, P Rossner Jr, A Milcova, J Schmuczerova… - Toxicology letters, 2011 - Elsevier
... Both effects are enhanced by metabolic activation by microsomal cytochrome P-450 enzymes. ...
Acellular assay to assess genotoxicity of complex mixtures of organic pollutants bound ... Effect
of cancer chemopreventive agents on microsome-mediated DNA adduction of the breast ...
Cited by 1 - Related articles - All 3 versions

Comparative oxidative metabolism of BDE-47 and BDE-99 by rat hepatic microsomes

CA Erratico, SC Moffatt… - Toxicological Sciences, 2011 - Soc Toxicology
... conducted using heat-denatured microsomes. Hepatic microsome samples were boiled for 5
min ... incubation mixture containing assay buffer, microsomes, and NADPH prior to use. Preliminary
experiments were conducted to determine the most active microsomal preparation ...
Related articles - All 2 versions

Induction of Human Microsomal Prostaglandin E Synthase 1 by Activated Oncogene RhoA GTPase in A549 Human Epithelial Cancer Cells

HJ Choi, SH Park, J Kim, KH Do… - Biochemical and Biophysical …, 2011 - Elsevier
... presence or absence of 10 M indomethacin for 24 h. Culture supernatant was analyzed for the
PGE2 secretion using an enzyme-linked immunosorbent assay. ... [20] Y. Moon, WC Glasgow, TE
Eling, Curcumin suppresses interleukin 1beta-mediated microsomal prostaglandin E ...

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