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Elastin Degradation and Vascular Smooth Muscle Cell Phenotype Change Precede Cell Loss and Arterial Medial Calcification in a Uremic Mouse Model of Chronic …

A Pai, EM Leaf, M El-Abbadi… - The American Journal of …, 2011 - Elsevier
Arterial medial calcification (AMC), a hallmark of vascular disease in uremic patients, is highly
correlated with serum phosphate levels and cardiovascular mortality. To determine the mechanisms
of AMC, mice were made uremic by partial right-side renal ablation (week 0), followed by ...
Cited by 2 - Related articles - All 4 versions

Complement Proteins C3 and C4 Bind to Collagen and Elastin in the Vascular Wall: A Potential Role in Vascular Stiffness and Atherosclerosis

KJ Shields, D Stolz, SC Watkins… - Clinical and …, 2011 - Wiley Online Library
Traditionally, perivascular adipose tissue (PVAT) has been regarded as an inert fat storage organ
and structrual support for the vasculature. More recently, visceral adipose has been increasingly
recognized as the largest endocrine organ in the body and a source of numerous ...
Related articles - All 2 versions

Liberation of Desmosine and Isodesmosine as Amino Acids from Insoluble Elastin by Elastolytic Proteases

H Umeda, M Aikawa… - Biochemical and Biophysical Research …, 2011 - Elsevier
The development of atherosclerotic lesions and abdominal aortic aneurysms involves degradation
and loss of extracellular matrix components, such as collagen and elastin. Releases of the elastin
cross-links desmosine (DES) and isodesmosine (IDE) may reflect elastin degradation in ...
All 2 versions

Inhibition of Transforming Growth Factor [beta] Worsens Elastin Degradation in a Murine Model of Kawasaki Disease

CM Alvira, C Guignabert, YM Kim, C Chen… - The American journal of …, 2011 - Elsevier
Kawasaki disease (KD) is an acute inflammatory illness marked by coronary arteritis.
However, the factors increasing susceptibility to coronary artery lesions are unknown. Because
transforming growth factor (TGF) β increases elastin synthesis and suppresses ...
Related articles - All 5 versions

In vivo estimation of the contribution of elastin and collagen to the mechanical properties in the human abdominal aorta: effect of age and sex

H Astrand, J STALHAND, J Karlsson… - Journal of applied …, 2011 - cat.inist.fr
The mechanical properties of the aorta affect cardiac function and are related to cardiovascular
morbidity/mortality. This study was designed to evaluate the isotropic (mainly elastin, elastin
iso ) and anisotropic (mainly collagen, collagen ani ) material parameters within the ...
All 2 versions

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