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Alterations in immune function and CYP450 activity of adult male deer mice following exposure to either 7, 12-dimethylbenz [a] anthracene or benzo [b] fluoranthene

J Liu, MM Peden-Adams, S Knuteson… - Toxicological & …, 2011 - Taylor & Francis
Adult male deer mice were exposed every other day for a period of 11 days to either 7,12-dimethylbenzanthracene
(DMBA; CAS# 57-97-6) or benzo[b]fluoranthene (BbF; CAS# 205-99-2) (0, 0.3, 1, 3, 10, or 30
mg kg −1 ). Immune endpoints assessed were lymphocyte proliferation, macrophage ...
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Hesperidin, a natural citrus flavonoglycoside, normalizes lipid peroxidation and membrane bound marker enzymes in 7, 12-Dimethylbenz (a) anthracene induced …

N Nandakumar, R Jayaprakash… - … & Preventive Nutrition, 2011 - Elsevier
Hesperidin a natural flavanoglycoside, has demonstrated a wide variety of biological activities
which make it a good candidate for the treatment of many oxidative stress mediated
diseases. The present study was aimed to evaluate its therapeutic potential by assaying ...

… expression in multiple components of the transforming growth factor-[beta] 1-induced Smad signaling pathway during 7, 12-dimethylbenz [a] anthracene-induced …

YK Chen, SH Yang, AHC Huang, SS Hsue… - Oral Oncology, 2011 - Elsevier
Transforming growth factor (TGF)-β1 signaling controls a plethora of cellular processes including
tumorigenesis. The TGF-β1 ligand initiates signaling by binding to TGF-βreceptor II (TβRII) and
allowing heterodimerization with TGF-βreceptor I (TβRI); thus, TβRI is phosphorylated by ...
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Antineoplastic effect of iodine and iodide in dimethylbenz [a] anthracene-induced mammary tumors: association between lactoperoxidase and estrogen-adduct …

O Soriano, G Delgado, B Anguiano… - Endocrine-Related …, 2011 - Soc Endocrinology
Several groups, including ours, have reported that iodine exhibited antiproliferative and apoptotic
effects in various cancer cells only if this element is supplemented as molecular iodine, or as
iodide, to cells that are able to oxidize it with the enzyme thyroperoxidase. In this study, ...

Role of 5-lipoxygenase in resveratrol mediated suppression of 7, 12-dimethylbenz ([alpha]) anthracene-induced mammary carcinogenesis in rats

M Chatterjee, S Das, M Janarthan… - European Journal of …, 2011 - Elsevier
Substantial evidences suggest that lipoxygenase-catalyzed products have a strong influence
on the development and progression of human cancers. The dietary phytochemical resveratrol
has become a focus of intense research owing to its roles in cancer prevention. A single ...

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