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[HTML] Characterisation of a Desmosterol Reductase Involved in Phytosterol Dealkylation in the Silkworm, Bombyx mori

[HTML] from plos.orgLF Ciufo, PA Murray, A Thompson, DJ Rigden… - PloS one, 2011 - dx.plos.org
Most species of invertebrate animals cannot synthesise sterols de novo and many that feed on
plants dealkylate phytosterols (mostly C 29 and C 28 ) yielding cholesterol (C 27 ). The final step
of this dealkylation pathway involves desmosterol reductase (DHCR24)-catalysed ...
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NMR-Derived Models of Amidopyrine and its Metabolites Complexed to Rabbit Cytochrome P450 2B4 Reveal a Structural Mechanism of Sequential N-Dealkylation

AG Roberts, SEA Sj gren, N Fomina, KT Vu… - Biochemistry, 2011 - ACS Publications
Biochemistry is published by the American Chemical Society. 1155 Sixteenth Street NW,
Washington, DC 20036 Published by American Chemical Society. Copyright © American Chemical
Society. However, no copyright claim is made to original US Government works, or works ...
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Engineering cytochrome P450 monooxygenase CYP 116B3 for high dealkylation activity

[PDF] from peerproject.euV Urlacher, L Liu… - 2011 - repository.peerproject.eu
Abstract Cytochrome P450 monooxygenase CYP- 116B3 from Rhodococcus ruber catalyzes
the deal- kylation of 7-ethoxycoumarin and the hydroxylation of substituted and unsubstituted
aromatics. How- ever, since activities were quite low, a combination of site-specific ...
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Drug Design Structural Alert: Formation of Trifluoroacetaldehyde Through N-Dealkylation is Linked to Testicular Lesions in Rat

ME Dowty, G Hu, F Hua, FB Shilliday… - International Journal of …, 2011 - ijt.sagepub.com
Abstract In the process of drug design, it is important to consider potential structural alerts that
may lead to toxicosis. This work illustrates how using trifluoroethane as a part of a novel chemical
entity led to cytochrome P450 – mediated N-dealkylation and the formation of ...

A Novel Sterol Desaturase-Like Protein Promoting Dealkylation of Phytosterols in Tetrahymena thermophila

ML Tomazic, SR Najle, AD Nusblat… - Eukaryotic …, 2011 - Am Soc Microbiol
The gene TTHERM_00438800 (DES24) from the ciliate Tetrahymena thermophila encodes a
protein with three conserved histidine clusters, typical of the fatty acid hydroxylase
superfamily. Despite its high similarity to sterol desaturase-like enzymes, the phylogenetic ...
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