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[PDF] Mapping of ESE-1 subdomains required to initiate mammary epithelial cell transformation via a cytoplasmic mechanism

[PDF] from molecular-cancer.comJD Prescott, JM Poczobutt, JJ Tentler… - Molecular …, 2011 - molecular-cancer.com
... directly test whether cytoplasmically restricted SAR protein is sufficient to initiate
transformation. To this end, we generated two independent stable MCF-12A
transfectant cell populations for GFP-NES1-SAR. As negative controls ...
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Reactive oxygen species mediate arsenic induced cell transformation and tumorigenesis through Wnt/[beta]-catenin pathway in human colorectal adenocarcinoma …

Z Zhang, X Wang, S Cheng, L Sun, Y Son… - Toxicology and Applied …, 2011 - Elsevier
... DLD1 cells were treated with arsenic, SOD and catalase for up to 2 weeks as described in the
“Cell transformation assay” section. The cells were used to test their tumorigenicity in nude mice. ...
To test if ROS are involved in the arsenic-induced cell transformation (Fig. ...

An international validation study of a Bhas 42 cell transformation assay for the prediction of chemical carcinogenicity

A Sakai, K Sasaki, K Hayashi, D Muramatsu… - … /Genetic Toxicology and …, 2011 - Elsevier
... In vitro cell transformation assays can supplement commonly used short-term test batteries and
provide for the ability to identify chemical carcinogens that fail to induce genotoxic responses
and would otherwise yield false negative results in genotoxicity tests [2], [3], [4] and [5]. A ...
Cited by 1

A steric blocker of translation elongation inhibits IGF-1R expression and cell transformation

S Lecosnier, C Cordier, P Simon, JC François… - The FASEB Journal, 2011 - FASEB
... IGF-1R is crucial for malignant transformation (42); therefore, we assessed the effects of PNA
959 on cell transformation. Anchorage-independent growth in the semisolid medium of soft agar
is a strong indicator of the transformed phenotype and a stringent test of mitogenic ...
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Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitors

F Chik… - Carcinogenesis, 2011 - Oxford Univ Press
... To test this hypothesis, we determined whether DNA demethylation in the presence of 5-azaCdR
continued after 48 h, a time ... When cell transformation was measured, DNMT1 depletion had the
strongest inhibitory effect and that was not enhanced by a triple depletion (Figure 5C ...
Cited by 2 - Related articles - All 5 versions

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