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SERPINA1 11478G> A Variant, Serum A1-Antitrypsin, Exacerbation Frequency And FEV1 Decline In COPD

JK Quint, GC Donaldson, M Kumari… - American Journal of …, 2011 - Am Thoracic Soc
C101 NEW INSIGHTS INTO ALPHA-1-ANTITRYPSIN DEFICIENCY AND OUTCOMES FOLLOWING
COPD EXACERBATIONS Poster Discussion Session / Tuesday, May 17/2:00 PM-4:30 PM / Korbel
Ballroom 4A-4B (Lower Level), Coloardo Convention ... Serpina1 11478g>a Variant, ...
All 3 versions

SERPINA1 11478G→ A variant, serum α1-antitrypsin, exacerbation frequency and FEV1 decline in COPD

JK Quint, GC Donaldson, M Kumari, PJ Talmud… - Thorax, 2011 - thorax.bmj.com
Contributors All authors contributed to the design and interpretation of data, and have approved
the final version of the manuscript. JRH devised the hypothesis for the study. JKQ coordinated
the London cohort studies and led the analysis of this data with GCD. The genotyping ...
Related articles - All 6 versions

Alpha-1 Antitrypsin PI MZ Heterozygosity Is Associated With COPD And CT Emphysema In The COPDGene Study

MG Foreman, DL DeMeo, CP Hersh… - American Journal of …, 2011 - Am Thoracic Soc
Morehouse School of Medicine, Atlanta, GA, Brigham and Women's Hospital, Boston, MA, National
Jewish Health, Denver, CO, 1 2 3 4 ... University of Colorado, Denver, CO, Johns Hopkins Bloomberg
School of Public Health, Baltimore, MD 5 ... The association between PI MZ alpha-1 ...
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Performance of enhanced liver fibrosis plasma markers in asymptomatic individuals with ZZ α1-antitrypsin deficiency

S Janciauskiene, A Wallmark… - European Journal of …, 2011 - journals.lww.com
Objectives: Alpha1-antitrypsin deficiency (AATD) is a common genetic cause of chronic liver
disease. According to retrospective studies, up to 25% of those with homozygous ZZ (Glu 342
to Lys) AATD suffer from liver cirrhosis and/or liver cancer in late adulthood. We ...
Related articles - All 4 versions

Alpha-1 Antitrypsin Deficiency: Importance of Proteasomal and Autophagic Degradative Pathways in Disposal of Liver Disease-Associated Protein Aggregates

D Perlmutter - Annual Review of Medicine, 2011 - annualreviews.org
Alpha-1-antitrypsin (AT) deficiency is the most common genetic cause of liver disease in
children. The primary pathological issue is a point mutation that renders an abundant hepatic
secretory glycoprotein prone to altered folding and a tendency to polymerize and ...
Cited by 1 - Related articles - All 2 versions

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