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ROCK-Driven Actomyosin Contractility Induces Tissue Stiffness and Tumor Growth

S Kümper… - Cancer Cell, 2011 - Elsevier
Tissues consist of cells and extracellular matrix (ECM), and cells are tightly linked to their extracellular
environment through adhesion receptors such as integrins. Within a tissue, remodeling of the
ECM can occur as part of normal physiological processes or in disease. ECM remodeling ...
All 2 versions

ROCK-Driven Actomyosin Contractility Induces Tissue Stiffness and Tumor Growth

C Marshall - CANCER CELL, 2011 - publications.icr.ac.uk
... ROCK-Driven Actomyosin Contractility Induces Tissue Stiffness and Tumor Growth. Kumper,
S., Marshall, CJ (2011) ROCK-Driven Actomyosin Contractility Induces Tissue Stiffness and
Tumor Growth. CANCER CELL, 19 (6). pp. 695-697. ISSN 1535-6108. ...
Cached

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and [beta]-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

MS Samuel, JI Lopez, EJ McGhee, DR Croft… - Cancer cell, 2011 - Elsevier
Tumors and associated stroma manifest mechanical properties that promote cancer. Mechanosensation
of tissue stiffness activates the Rho/ROCK pathway to increase actomyosin-mediated cellular
tension to re-establish force equilibrium. To determine how actomyosin tension affects ...
Cited by 1 - Related articles - All 3 versions

Actomyosin-generated tension controls the molecular kinetics of focal adhesions

H Wolfenson, A Bershadsky, YI Henis… - Journal of Cell …, 2011 - jcs.biologists.org
Focal adhesions (FAs) have key roles in the interaction of cells with the extracellular matrix
(ECM) and in adhesion-mediated signaling. These dynamic, multi-protein structures sense the
ECM both chemically and physically, and respond to external and internal forces by ...
Cited by 2 - Related articles - All 3 versions

Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding

[PDF] from stowers-institute.orgMP Stewart, J Helenius, Y Toyoda, SP Ramanathan… - Nature, 2011 - nature.com
During mitosis, adherent animal cells undergo a drastic shape change, from essentially flat to
round 1, 2, 3 . Mitotic cell rounding is thought to facilitate organization within the mitotic cell and
be necessary for the geometric requirements of division 4, 5, 6, 7 . However, the forces ...
Cited by 12 - Related articles - All 9 versions

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