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Loss of AS160 causes Glut4 to accumulate in compartments that are primed for fusion in basal adipocytes

PD Brewer, I Romenskaia, MA Kanow… - Journal of Biological …, 2011 - ASBMB
The Akt substrate AS160 (TCB1D4) regulates Glut4 exocytosis; shRNA knockdown of AS160
increases surface Glut4 in basal adipocytes. AS160 knockdown is only partially insulin
mimetic, insulin further stimulates Glut4 translocation in these cells. Insulin regulates ...
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In obese Zucker rats, lipids accumulate in the heart despite normal mitochondrial content, morphology and long‐chain fatty acid oxidation

GP Holloway, LA Snook, RJ Harris… - The Journal of …, 2011 - Wiley Online Library
The storage of fat within the heart muscle has been associated with reductions in force
production, which has implications for the ability of the heart to adequately pump blood. With
the assistance of membrane proteins known as transport proteins, fats from the blood can ...
Cited by 2 - Related articles - All 4 versions

Diverse polyubiquitin chains accumulate following 26S proteasomal dysfunction in mammalian neurones

L Bedford, R Layfield, RJ Mayer, J Peng… - Neuroscience letters, 2011 - Elsevier
A generality has been that polyubiquitin chain linkage can differentially address proteins for various
physiological processes. 26S proteasomal degradation is the most established function of ubiquitin
signalling, classically linked to Lys48 polyubiquitin chains. The other well-characterised ...
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How organic anions accumulate in hepatocytes lacking Mrp2: evidence in rat liver

P Millet, M Moulin, B Stieger, Y Daali… - Journal of Pharmacology …, 2011 - ASPET
In the liver, the accumulation of hepatobiliary contrast agents is a crucial issue to understand
the images of liver scintigraphy or magnetic resonance (MR) imaging. Thus, depending on the
regulation of uptake and exit membrane systems in normal and injured hepatocytes, ...
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C-Kit-Positive Cells Accumulate in Remodeled Vessels of Idiopathic Pulmonary Arterial Hypertension

[HTML] from 171.66.122.149D Montani, F Perros, N Gambaryan… - American Journal of …, 2011 - 171.66.122.149
Measurements and Main Results: Infiltration of c-kit + cells in pulmonary arterial lesions was
associated with an increase in c-kit mRNA expression (P < 0.01 compared with control
subjects). Both c-kit + /tryptase + mast cells and c-kit + /tryptase – BM-derived cells were ...
Cited by 3 - Related articles - All 5 versions

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