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Etiology and Genetics of Human Narcolepsy

E Mignot - Narcolepsy, 2011 - Springer
Low levels of the neuropeptide hypocretin-1 (hcrt-1, also called orexin-A) are found in the cerebrospinal
fluid (CSF) of most people with narcolepsy with cataplexy and in some without cataplexy
[1–6]. As a result, in the most recent revision of the International Classification of Sleep ...

Sleep Homeostasis, Adenosine, Caffeine, and Narcolepsy

HP Landolt - Narcolepsy, 2011 - Springer
Many functional aspects of wakefulness and sleep, including excessive daytime sleepiness,
vigilance, attention, sleep structure, and quantita- tive measures derived from the
electroencephalo- gram (EEG) are tightly controlled by two interacting processes: (1) a ...

Parasomnias in Narcolepsy with Cataplexy

Y Dauvilliers… - Narcolepsy, 2011 - Springer
Narcolepsy with cataplexy is a disabling disorder characterized by excessive daytime sleepiness
(EDS) and abnormal rapid eye movement (REM) sleep manifestations including cataplexy (sudden
loss of muscle tone triggered by strong emotions), sleep paralysis, hypnagogic ...

The Serotoninergic System in Sleep and Narcolepsy

C Alexandre… - Narcolepsy, 2011 - Springer
Over 60 years ago, researchers discovered that a blood-borne substance increased vascular
tone and intestinal motility by constricting smooth muscle. They named this substance serotonin
based on the Latin word serum and the Greek word tonic, and soon after, this factor was ...

Treatment of Narcolepsy in Children

M Lecendreux - Narcolepsy, 2011 - Springer
Narcolepsy is a chronic primary sleep-wake disor- der, characterized by excessive daytime sleepiness
(EDS), sudden sleep episodes, and attacks of mus- cle atonia mostly triggered by emotions
(cata- plexy). Narcolepsy is a lifelong disorder, however, not progressive, and occurrence ...

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