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Milestones in huntington disease

I Shoulson… - Movement Disorders, 2011 - Wiley Online Library
In 1872, George Huntington described the key hereditary and clinical features of the disorder
that was to bear his name,1 in the same era when Gregor Mendel was formulating the fundamental
principles of genetics. Many decades passed before the significance of Huntington's ...
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Cystamine and ethyl-eicosapentaenoic acid treatment fail to prevent malonate-induced striatal toxicity in mice

SN Sivananthan… - Neurobiology of Aging, 2011 - Elsevier
... Abstract. Cystamine has demonstrated neuroprotective activity in a variety of studies, and is
currently being evaluated in a human clinical trial in Huntington's disease (HD). ... Keywords:
Huntington disease; Mouse models; Malonate; Cystamine; Neurodegeneration; Striatum. ...
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The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease

I Munoz-Sanjuan… - J Clin Invest, 2011 - Am Soc Clin Investig
Huntington disease (HD) is a dominantly inherited neurodegenerative disorder that results from
expansion of the polyglutamine repeat in the huntingtin (HTT) gene. There are currently no effective
treatments for this devastating disease. Given its monogenic nature, disease modification ...
Cited by 1 - Related articles - All 3 versions

[HTML] Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

[HTML] from nih.govJ Labbadia, H Cunliffe, A Weiss… - The Journal of clinical …, 2011 - ncbi.nlm.nih.gov
Huntington disease (HD) is a devastating neurodegenerative disorder for which there are no
disease-modifying treatments. Previous studies have proposed that activation of the heat shock
response (HSR) via the transcription factor heat shock factor 1 (HSF1) may be of ...

Brain networks in Huntington disease

D Eidelberg… - J Clin Invest, 2011 - Am Soc Clin Investig
Recent studies have focused on understanding the neural mechanisms underlying the emergence
of clinical signs and symptoms in early stage Huntington disease (HD). Although cell-based assays
have focused on cell autonomous effects of mutant huntingtin, animal HD models have ...
Cited by 2 - Related articles - All 3 versions

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