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KG Wolter - 2012 - gradworks.umi.com
Metastatic melanoma has proven exceptionally difficult to treat, in part due to consistent defects
in cell death pathways. The overexpression of antiapoptosis proteins from the Bcl-2 family is
a hallmark of melanoma progression. Past strategies targeting these proteins have ...
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JA Freedman, DS Tyler, JR Nevins… - The American Journal of …, 2011 - Elsevier
A defining characteristic of most human cancers is heterogeneity, resulting from the somatic acquisition
of a complex array of genetic and genomic alterations. Dissecting this heterogeneity is critical
to developing an understanding of the underlying mechanisms of disease and to paving ...
Related articles - All 4 versions
RN Shore, P Shore, NM Monahan… - Journal of drugs in …, 2011 - ncbi.nlm.nih.gov
Objective: To determine the effectiveness of a serial screening program in achieving early detection
and preventing death in patients at increased risk for melanoma. Design: Retrospective
study. Setting: Private dermatology practice. Patients: The study included all patients at ...
N McCarthy - Nature Reviews Cancer, 2011 - nature.com
Malignant melanoma remains a difficult cancer to treat owing to its aggressive nature and frequent
resistance to chemotherapeutic drugs. Sunburn during childhood has been associated with increased
risk of melanoma development, and in a recent Nature paper, M. ... To read this article in ...
All 3 versions
M Berwick - Melanoma Development, 2011 - Springer
Abstract Melanoma is steadily increasing in incidence while mortality is steady or only increasing
slightly. Patterns of incidence, including anatomic site, differ by age and sex as well as geographic
location. Light pigmentation and multiple nevi are critical risk factors for the development ...
Cited by 72 - Related articles - BL Direct - All 6 versions

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