This journal publishes scholarly reviews and experimental papers that address the state of the art in the management of allergic and immunologic diseases and in particular place newly available data into perspective. Each issue of the journal is devoted to a single theme of critical importance to allergists and immunologists, with the goal of providing a comprehensive treatment of the subject that will benefit a wide readership. Readers will find the journal of value in elucidating the impact of novel data on clinical management against the background of advances such as the development of standardized protocols for allergy skin testing and challenge procedures and improved understanding of cell biology. The ultimate objective is to help improve the care and management of patients with immune-mediated disease.